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Tbio
PHKB
Phosphorylase b kinase regulatory subunit beta

Protein Summary
Description
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentrat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299167
  • ENSP00000299167
  • ENSG00000102893
  • ENST00000323584
  • ENSP00000313504
  • ENST00000566044
  • ENSP00000456729
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
virus perturbation
0.92
drug perturbation
0.87
transcription factor binding site profile
0.81
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.28   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
1 – 10 of 51
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999999988
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.554
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.999937384
p_ni:  0.000062615
Score:  0.229
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.999843217
p_ni:  0.000156584
p_wrong:  1.99e-7
Score:  0.613
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.998072122
p_ni:  0.001927773
p_wrong:  1.05e-7
Data Source:  BioPlex
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.99751703
p_ni:  0.002482255
p_wrong:  7.15e-7
Score:  0.16
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.996289464
p_ni:  0.00370994
p_wrong:  5.97e-7
Data Source:  BioPlex
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.993600348
p_ni:  0.006334651
p_wrong:  0.000065001
Data Source:  BioPlex
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.985598936
p_ni:  0.014400789
p_wrong:  2.75e-7
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.913555056
p_ni:  0.082449514
p_wrong:  0.003995429
Data Source:  BioPlex
Pathways (57)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
42.3
platelet crit
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
42.3
platelet crit
1
5.4
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase regulatory subunit beta
VGNC:10146
465150
Macaque
phosphorylase kinase regulatory subunit beta
716390
Mouse
MGI:97578
102093
Rat
RGD:620186
361377
Dog
phosphorylase kinase regulatory subunit beta
VGNC:44498
478139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase regulatory subunit beta
Macaque
phosphorylase kinase regulatory subunit beta
Mouse
Rat
Dog
phosphorylase kinase regulatory subunit beta
Publication Statistics
PubMed Score 16.28
PubMed score by year
PubTator Score 10.15
PubTator score by year