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Tbio
HGD
Homogentisate 1,2-dioxygenase

Protein Summary
Description
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283871
  • ENSP00000283871
  • ENSG00000113924

Symbol
  • HGO
  • AKU
  • HGO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
cell line
0.55
metabolite
0.45
chemical
0.44
disease
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homogentisate 1,2-dioxygenase
VGNC:7066
460613
Macaque
homogentisate 1,2-dioxygenase
713499
Mouse
MGI:96078
15233
Rat
RGD:1308757
360719
Dog
homogentisate 1,2-dioxygenase
VGNC:41673
478578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homogentisate 1,2-dioxygenase
Macaque
homogentisate 1,2-dioxygenase
Mouse
Rat
Dog
homogentisate 1,2-dioxygenase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q93099-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Phenylalanine and tyrosine metabolism
Reactome
Tyrosine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Phenylalanine and tyrosine metabolism
Tyrosine catabolism
Protein-Protein Interactions (114)
1 – 10 of 114
HPD
Tclin
Family: Enzyme
Novelty: 0.00515372
Score: 0.998
Data Source: STRINGDB
GSTZ1
Tbio
Family: Enzyme
Novelty: 0.00929957
Score: 0.991
Data Source: STRINGDB
FAH
Tbio
Family: Enzyme
Novelty: 0.00456617
Score: 0.974
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.945
Data Source: STRINGDB
HPDL
Tdark
Family: Enzyme
Novelty: 0.3445048
Score: 0.908
Data Source: STRINGDB
TAT
Tbio
Family: Enzyme
Novelty: 0.00079176
Score: 0.867
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.787
Data Source: STRINGDB
FTCD
Tbio
Family: Enzyme
Novelty: 0.02266041
Score: 0.771
Data Source: STRINGDB
HAAO
Tbio
Family: Enzyme
Novelty: 0.02869073
Score: 0.758
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.67

PubMed score by year
PubTator Score  227.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer