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Tbio
WNT8B
Protein Wnt-8b

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343737
  • ENSP00000340677
  • ENSG00000075290
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.58
biological process
0.57
tissue
0.49
gene perturbation
0.45
microRNA
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 8B
VGNC:9783
466182
Macaque
Wnt family member 8B
710242
Mouse
MGI:109485
22423
Rat
RGD:1307644
293990
Dog
Wnt family member 8B
VGNC:48430
486841
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 8B
Macaque
Wnt family member 8B
Mouse
Rat
Dog
Wnt family member 8B
Pathways (90)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (148)
1 – 10 of 148
SFRP1
Tchem
Novelty: 0.00285799
Score: 0.983
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.977
Data Source: Reactome,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.975
Data Source: STRINGDB
DKK1
Tchem
Novelty: 0.00117121
Score: 0.974
Data Source: STRINGDB
FZD8
Tbio
Family: GPCR
Novelty: 0.01613553
Score: 0.971
Data Source: STRINGDB
SFRP2
Tbio
Novelty: 0.00454703
Score: 0.971
Data Source: STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.971
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.97
Data Source: Reactome,STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.97
Data Source: STRINGDB
AXIN1
Tbio
Novelty: 0.00175842
Score: 0.97
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  53.33

PubMed score by year
PubTator Score  10.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer