Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development. This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
- ENST00000369684
- ENSP00000358698
- ENSG00000134245
- ENST00000369686
- ENSP00000358700
- WNT13
- WNT13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.83 | ||
transcription factor | 0.76 | ||
biological process | 0.68 | ||
pathway | 0.68 | ||
PubMedID | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 120.26 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 226 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 120.26 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 226 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 4 | 7 | 96.5 | |||||
mean platelet volume | 2 | 2 | 2 | 91.4 | |||||
testosterone measurement | 2 | 2 | 2 | 88.5 | |||||
1 | 2 | 2 | 86.8 | ||||||
diastolic blood pressure | 3 | 3 | 4 | 85.8 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 7 | 96.5 | |||||
mean platelet volume | 2 | 91.4 | |||||
testosterone measurement | 2 | 88.5 | |||||
2 | 86.8 | ||||||
diastolic blood pressure | 4 | 85.8 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 2B | VGNC:10884 | 457103 | |||||
Macaque | Wnt family member 2B | 705773 | ||||||
Mouse | MGI:1261834 | 22414 | ||||||
Rat | RGD:69346 | 116466 | ||||||
Dog | Wnt family member 2B | VGNC:48423 | 483220 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 2B | |||||
Macaque | Wnt family member 2B | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 2B | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (58)
Reactome (6)
KEGG (13)
PathwayCommons (29)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Gene Ontology Terms (19)
Functions (1)
Components (3)
Processes (15)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (136)
1 – 10 of 136
FZD1
Family: GPCR
Novelty: 0.01097201
Score: 0.979
Data Source: STRINGDB
FZD4
Family: GPCR
Novelty: 0.00577957
Score: 0.977
Data Source: STRINGDB
FZD2
Family: GPCR
Novelty: 0.00774893
Score: 0.977
Data Source: STRINGDB
FZD8
Family: GPCR
Novelty: 0.01613553
Score: 0.974
Data Source: STRINGDB
FZD7
Family: GPCR
Novelty: 0.00916448
Score: 0.973
Data Source: STRINGDB
FZD6
Family: GPCR
Novelty: 0.01425136
Score: 0.972
Data Source: STRINGDB
FZD9
Family: GPCR
Novelty: 0.01414546
Score: 0.972
Data Source: STRINGDB
FZD5
Family: GPCR
Novelty: 0.01673829
Score: 0.971
Data Source: STRINGDB
FZD10
Family: GPCR
Novelty: 0.02786933
Score: 0.967
Data Source: STRINGDB
WLS
Novelty: 0.01459149
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score 120.26
PubMed score by year
PubTator Score 47.17
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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