Protein Summary
Receptor for ATP that acts as a ligand-gated ion channel. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
- ENST00000225328
- ENSP00000225328
- ENSG00000083454
- ENST00000345901
- ENSP00000342161
- ENST00000547178
- ENSP00000448355
- ENST00000551178
- ENSP00000447545
- P2X5
- P2X5
- LRH-1
- P2X5R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
gene perturbation | 0.77 | ||
histone modification site profile | 0.67 | ||
disease perturbation | 0.62 | ||
small molecule perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.78 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.78 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (68)
FAM126A
Novelty: 0.0250547
p_int: 0.994979753
p_ni: 0.003531591
p_wrong: 0.001488656
Score: 0.177
Data Source: BioPlex,STRINGDB
STK17B
Family: Kinase
Novelty: 0.0420158
p_int: 0.994173003
p_ni: 0.005622384
p_wrong: 0.000204613
Data Source: BioPlex
ITPA
Family: Enzyme
Novelty: 0.00235169
p_int: 0.993821766
p_ni: 0.005404968
p_wrong: 0.000773265
Data Source: BioPlex
ARV1
Novelty: 0.03235632
p_int: 0.989083811
p_ni: 0.010916171
p_wrong: 1.9e-8
Data Source: BioPlex
GALNS
Family: Enzyme
Novelty: 0.00510529
p_int: 0.978409924
p_ni: 0.021436677
p_wrong: 0.000153399
Data Source: BioPlex
DPH1
Novelty: 0.02296024
p_int: 0.948906547
p_ni: 0.051087262
p_wrong: 0.000006191
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Reactome | Platelet calcium homeostasis | ||||
Reactome | Platelet homeostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Platelet calcium homeostasis | ||||
Platelet homeostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (6)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 60.78
PubMed score by year
PubTator Score 44.77
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (25)
GeneRif Annotations (13)
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