Tchem P2RX5 P2X purinoceptor 5

Protein Classes

DTO Classes

Protein / Ion Channel / Atp-gated P2x Receptor Cation Channel (P2x Receptor) Family / P2x Purinoceptor 5

Protein Summary

Description

Receptor for ATP that acts as a ligand-gated ion channel. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q93086
• G5E981
• O43450
• O75540
• Q308M5
• Q59F38
• Q8IXW4
• Q93087
• Q9NZV0
• P2X5

Gene Name

• P2RX5

Ensembl ID

• ENST00000225328
• ENSP00000225328
• ENSG00000083454
• ENST00000345901
• ENSP00000342161
• ENST00000547178
• ENSP00000448355
• ENST00000551178
• ENSP00000447545

Symbol

• P2X5
• P2X5
• LRH-1
• P2X5R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
gene perturbation	0.77
histone modification site profile	0.67
disease perturbation	0.62
small molecule perturbation	0.54

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.91   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.91   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

adenosine triphosphate

P2RX5Tchem IC

EC50 : 6

suramin

P2RX5Tchem IC

IC50 : 5.4000001

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q93086-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)

Reactome (4)

KEGG (2)

Elevation of cytosolic Ca2+ levels (R-HSA-139853)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Platelet calcium homeostasis	28 targets	R-HSA-418360
Reactome	Platelet homeostasis	88 targets	R-HSA-418346

Name	Explore in Pharos	Explore in Source
Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Hemostasis	666 targets	R-HSA-109582
Platelet calcium homeostasis	28 targets	R-HSA-418360
Platelet homeostasis	88 targets	R-HSA-418346

Gene Ontology Terms (20)

Functions (6)

Components (6)

Processes (8)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
ATP-gated ion channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
extracellularly ATP-gated cation channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
purinergic nucleotide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ion channel activity	Traceable Author Statement (TAS)	ProtInc
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Non-traceable Author Statement (NAS)	BHF-UCL

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

DNAJB9

Tbio

Novelty: 0.00536296

p_int: 0.998390524

p_ni: 0.001609476

Data Source: BioPlex

HLA-A

Tbio

Novelty: 0.00270731

p_int: 0.99727634

p_ni: 0.00272366

Data Source: BioPlex

FAM126A

Tbio

Novelty: 0.0250547

p_int: 0.994979753

p_ni: 0.003531591

p_wrong: 0.001488656

Score: 0.177

Data Source: BioPlex,STRINGDB

STK17B

Tchem

Family: Kinase

Novelty: 0.0420158

p_int: 0.994173003

p_ni: 0.005622384

p_wrong: 0.000204613

Data Source: BioPlex

ITPA

Tbio

Family: Enzyme

Novelty: 0.00235169

p_int: 0.993821766

p_ni: 0.005404968

p_wrong: 0.000773265

Data Source: BioPlex

ARV1

Tbio

Novelty: 0.03235632

p_int: 0.989083811

p_ni: 0.010916171

p_wrong: 1.9e-8

Data Source: BioPlex

GALNS

Tbio

Family: Enzyme

Novelty: 0.00510529

p_int: 0.978409924

p_ni: 0.021436677

p_wrong: 0.000153399

Data Source: BioPlex

TTC17

Tdark

Novelty: 0.79373597

p_int: 0.950154485

p_ni: 0.049845515

Data Source: BioPlex

DPH1

Tbio

Novelty: 0.02296024

p_int: 0.948906547

p_ni: 0.051087262

p_wrong: 0.000006191

Data Source: BioPlex

CANX

Tbio

Novelty: 0.00087002

p_int: 0.93928535

p_ni: 0.06071465

Data Source: BioPlex

Publication Statistics

PubMed Score  56.91

PubMed score by year

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PubTator Score  44.77

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Receptor
Reference proteome

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging