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Tchem
P2RX5
P2X purinoceptor 5

Protein Summary
Description
Receptor for ATP that acts as a ligand-gated ion channel. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225328
  • ENSP00000225328
  • ENSG00000083454
  • ENST00000345901
  • ENSP00000342161
  • ENST00000547178
  • ENSP00000448355
  • ENST00000551178
  • ENSP00000447545

Symbol
  • P2X5
  • P2X5
  • LRH-1
  • P2X5R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.77
histone modification site profile
0.67
disease perturbation
0.62
small molecule perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.26   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.26   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.998390524
p_ni:  0.001609476
Data Source:  BioPlex
P10314
Tbio
Novelty:  0.00270731
p_int:  0.99727634
p_ni:  0.00272366
Data Source:  BioPlex
FAM126A
Tbio
Novelty:  0.0250547
p_int:  0.994979753
p_ni:  0.003531591
p_wrong:  0.001488656
Score:  0.177
Data Source:  BioPlex,STRINGDB
STK17B
Tchem
Family:  Kinase
Novelty:  0.0420158
p_int:  0.994173003
p_ni:  0.005622384
p_wrong:  0.000204613
Data Source:  BioPlex
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.993821766
p_ni:  0.005404968
p_wrong:  0.000773265
Data Source:  BioPlex
ARV1
Tbio
Novelty:  0.03235632
p_int:  0.989083811
p_ni:  0.010916171
p_wrong:  1.9e-8
Data Source:  BioPlex
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.978409924
p_ni:  0.021436677
p_wrong:  0.000153399
Data Source:  BioPlex
TTC17
Tdark
Novelty:  0.79373597
p_int:  0.950154485
p_ni:  0.049845515
Data Source:  BioPlex
DPH1
Tbio
Novelty:  0.02296024
p_int:  0.948906547
p_ni:  0.051087262
p_wrong:  0.000006191
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.93928535
p_ni:  0.06071465
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Reactome
Platelet calcium homeostasis
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
Hemostasis
Platelet calcium homeostasis
Platelet homeostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 57.26
PubMed score by year
PubTator Score 44.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title