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Tchem
ATP2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309890
  • ENSP00000312577
  • ENSG00000074370
  • ENST00000352011
  • ENSP00000301387
  • ENST00000359983
  • ENSP00000353072
  • ENST00000397035
  • ENSP00000380229
  • ENST00000397041
  • ENSP00000380234
  • ENST00000397043
  • ENSP00000380236

Symbol
  • SERCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
PubMedID
0.95
interacting protein
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.17   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.17   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
76
mean platelet volume
2
2
2
73.4
3
2
0
1
57.7
platelet count
1
1
1
56.2
Agents acting on the renin-angiotensin system use measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
76
mean platelet volume
2
73.4
0
1
57.7
platelet count
1
56.2
Agents acting on the renin-angiotensin system use measurement
1
46.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
VGNC:9127
100613278
Macaque
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
707768
Mouse
MGI:1194503
53313
Rat
RGD:2175
25391
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
VGNC:38255
491437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Macaque
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Mouse
Rat
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q93084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (108)
1 – 10 of 108
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999998744
p_ni:  0.000001256
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.999962985
p_ni:  0.000037015
Data Source:  BioPlex
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999948443
p_ni:  0.000051557
Score:  0.18
Data Source:  BioPlex,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.999643244
p_ni:  0.000356756
Data Source:  BioPlex
TREML2
Tbio
Novelty:  0.05038302
p_int:  0.999519422
p_ni:  0.000480578
Score:  0.183
Data Source:  BioPlex,STRINGDB
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.99910368
p_ni:  0.00089632
Score:  0.177
Data Source:  BioPlex,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.998287534
p_ni:  0.001712466
Data Source:  BioPlex
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.99818604
p_ni:  0.001813959
Score:  0.182
Data Source:  BioPlex,STRINGDB
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.998053243
p_ni:  0.001946757
Score:  0.233
Data Source:  BioPlex,STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.997284761
p_ni:  0.002715239
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  115.17

PubMed score by year
PubTator Score  192.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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