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Tdark
HIST1H2AC
Histone H2A type 1-C

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314088
  • ENSP00000321389
  • ENSG00000180573
  • ENST00000377791
  • ENSP00000367022
  • ENST00000602637
  • ENSP00000473534

Symbol
  • H2AFL
  • H2A/l
  • H2AFL
  • dJ221C16.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
transcription factor perturbation
0.84
transcription factor binding site profile
0.82
small molecule perturbation
0.8
tissue sample
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (400)
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.996
Data Source:  STRINGDB
HIST1H2BK
Tbio
Novelty:  0.12867647
Score:  0.996
Data Source:  STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
Score:  0.996
Data Source:  STRINGDB
HIST1H2BD
Tbio
Novelty:  0.05094332
Score:  0.995
Data Source:  STRINGDB
HIST1H2AJ
Tdark
Novelty:  0.70360784
Score:  0.995
Data Source:  STRINGDB
H2AFJ
Tbio
Novelty:  0.34726304
Score:  0.995
Data Source:  STRINGDB
HIST1H2AH
Tbio
Novelty:  0.09573052
Score:  0.994
Data Source:  STRINGDB
HIST1H2BC
Tbio
Novelty:  0.03524801
Score:  0.991
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.99
Data Source:  STRINGDB
HIST1H2BO
Tdark
Novelty:  0.3427419
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (83)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 80
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (82)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
7
10
99.6
hemoglobin measurement
5
6
7
99.4
hematocrit
6
6
10
99.3
mean corpuscular hemoglobin concentration
10
5
15
99.1
mean corpuscular volume
5
5
8
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.6
hemoglobin measurement
7
99.4
hematocrit
10
99.3
mean corpuscular hemoglobin concentration
15
99.1
mean corpuscular volume
8
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.39
PubMed score by year
PubTator Score 2.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title