Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
- ENST00000314088
- ENSP00000321389
- ENSG00000180573
- ENST00000377791
- ENSP00000367022
- ENST00000602637
- ENSP00000473534
- H2AFL
- H2A/l
- H2AFL
- dJ221C16.4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.9 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.82 | ||
small molecule perturbation | 0.8 | ||
tissue sample | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.39 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.39 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (400)
Nearest Tclin Targets
Pathways (83)
Reactome (80)
KEGG (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (82)
Items per page:
1 – 5 of 82
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 7 | 10 | 99.6 | |||||
hemoglobin measurement | 5 | 6 | 7 | 99.4 | |||||
hematocrit | 6 | 6 | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 10 | 5 | 15 | 99.1 | |||||
mean corpuscular volume | 5 | 5 | 8 | 99 | |||||
Items per page:
1 – 5 of 82
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 10 | 99.6 | |||||
hemoglobin measurement | 7 | 99.4 | |||||
hematocrit | 10 | 99.3 | |||||
mean corpuscular hemoglobin concentration | 15 | 99.1 | |||||
mean corpuscular volume | 8 | 99 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 1.39
PubMed score by year
PubTator Score 2.69
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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