Protein Classes
Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
- ENST00000314088
- ENSP00000321389
- ENSG00000180573
- ENST00000377791
- ENSP00000367022
- ENST00000602637
- ENSP00000473534
- H2AFL
- H2A/l
- H2AFL
- dJ221C16.4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.9 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.82 | ||
small molecule perturbation | 0.8 | ||
tissue sample | 0.77 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.35 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.35 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 1 | 1 | 1 | 67.2 | |||||
1 | 1 | 0 | 1.7 | 41.4 | |||||
1 | 1 | 0 | 1.3 | 36.6 | |||||
intelligence | 1 | 1 | 1 | 34.3 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 13.2 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 1 | 67.2 | |||||
0 | 1.7 | 41.4 | |||||
0 | 1.3 | 36.6 | |||||
intelligence | 1 | 34.3 | |||||
monocyte percentage of leukocytes | 1 | 13.2 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (83)
Reactome (80)
KEGG (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 80
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Amyloid fiber formation | ||||
B-WICH complex positively regulates rRNA expression | ||||
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (400)
1 – 10 of 400
HIST2H2AC
Novelty: 0.00065524
Score: 0.996
Data Source: STRINGDB
HIST1H2BK
Novelty: 0.12867647
Score: 0.996
Data Source: STRINGDB
HIST2H2AB
Novelty: 0.06772132
Score: 0.996
Data Source: STRINGDB
HIST1H2BD
Novelty: 0.05094332
Score: 0.995
Data Source: STRINGDB
HIST1H2AJ
Novelty: 0.70360784
Score: 0.995
Data Source: STRINGDB
H2AFJ
Novelty: 0.34726304
Score: 0.995
Data Source: STRINGDB
HIST1H2AH
Novelty: 0.09573052
Score: 0.994
Data Source: STRINGDB
HIST1H2BC
Novelty: 0.03524801
Score: 0.991
Data Source: STRINGDB
HIST2H2BE
Novelty: 0.00024381
Score: 0.99
Data Source: STRINGDB
HIST1H2BO
Novelty: 0.3427419
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score 1.35
PubMed score by year
PubTator Score 2.69
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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