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Tdark
HIST1H2AC
Histone H2A type 1-C

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314088
  • ENSP00000321389
  • ENSG00000180573
  • ENST00000377791
  • ENSP00000367022
  • ENST00000602637
  • ENSP00000473534

Symbol
  • H2AFL
  • H2A/l
  • H2AFL
  • dJ221C16.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
transcription factor perturbation
0.84
transcription factor binding site profile
0.82
small molecule perturbation
0.8
tissue sample
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
67.2
1
1
0
1.7
41.4
1
1
0
1.3
36.6
intelligence
1
1
1
34.3
monocyte percentage of leukocytes
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
67.2
0
1.7
41.4
0
1.3
36.6
intelligence
1
34.3
monocyte percentage of leukocytes
1
13.2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q93077-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (83)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 80
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (400)
1 – 10 of 400
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.996
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.996
Data Source: STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
Score: 0.996
Data Source: STRINGDB
HIST1H2BD
Tbio
Novelty: 0.05094332
Score: 0.995
Data Source: STRINGDB
HIST1H2AJ
Tdark
Novelty: 0.70360784
Score: 0.995
Data Source: STRINGDB
H2AFJ
Tbio
Novelty: 0.34726304
Score: 0.995
Data Source: STRINGDB
HIST1H2AH
Tbio
Novelty: 0.09573052
Score: 0.994
Data Source: STRINGDB
HIST1H2BC
Tbio
Novelty: 0.03524801
Score: 0.991
Data Source: STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.99
Data Source: STRINGDB
HIST1H2BO
Tdark
Novelty: 0.3427419
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.35

PubMed score by year
PubTator Score  2.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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