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Tdark
TATDN2
Putative deoxyribonuclease TATDN2

Protein Summary
Description
Putative deoxyribonuclease.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287652
  • ENSP00000287652
  • ENSG00000157014
  • ENST00000448281
  • ENSP00000408736

Symbol
  • KIAA0218
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
virus perturbation
0.79
transcription factor binding site profile
0.77
cell type or tissue
0.65
gene perturbation
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
91.6
eosinophil percentage of leukocytes
2
3
3
83.3
eosinophil percentage of granulocytes
1
1
1
40.7
self reported educational attainment
1
1
1
31.4
sum of eosinophil and basophil counts
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.6
eosinophil percentage of leukocytes
3
83.3
eosinophil percentage of granulocytes
1
40.7
self reported educational attainment
1
31.4
sum of eosinophil and basophil counts
1
28.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TatD DNase domain containing 2
460166
Macaque
TatD DNase domain containing 2
701390
Mouse
MGI:3576210
381801
Rat
RGD:1586017
500295
Dog
TatD DNase domain containing 2
484656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TatD DNase domain containing 2
Macaque
TatD DNase domain containing 2
Mouse
Rat
Dog
TatD DNase domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q93075-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Protein-Protein Interactions (30)
1 – 10 of 30
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.999060849
p_ni:  0.000655345
p_wrong:  0.000283807
Score:  0.189
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.998535796
p_ni:  0.001143732
p_wrong:  0.000320472
Score:  0.161
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.997209304
p_ni:  0.000049064
p_wrong:  0.002741632
Data Source:  BioPlex
CCDC174
Tdark
Novelty:  0.37189828
Score:  0.903
Data Source:  STRINGDB
CNNM4
Tbio
Novelty:  0.04199329
Score:  0.578
Data Source:  STRINGDB
SMPDL3A
Tbio
Family:  Enzyme
Novelty:  0.14245461
Score:  0.577
Data Source:  STRINGDB
PRRT3
Tdark
Novelty:  0.32860844
Score:  0.576
Data Source:  STRINGDB
PPP1R35
Tdark
Family:  Enzyme
Novelty:  0.47022173
Score:  0.571
Data Source:  STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
Score:  0.571
Data Source:  STRINGDB
MLNR
Tchem
Family:  GPCR
Novelty:  0.0048579
Score:  0.528
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.00

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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