You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MED12
Mediator of RNA polymerase II transcription subunit 12

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374080
  • ENSP00000363193
  • ENSG00000184634
  • ENST00000374102
  • ENSP00000363215

Symbol
  • ARC240
  • CAGH45
  • HOPA
  • KIAA0192
  • TNRC11
  • TRAP230
  • OKS
  • FGS1
  • HOPA
  • OPA1
  • OHDOX
  • ARC240
  • CAGH45
  • MED12S
  • TNRC11
  • TRAP230
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.95
interacting protein
0.93
biological process
0.81
phenotype
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.95   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 234.95   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
73.8
reticulocyte count
2
1
2
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
73.8
reticulocyte count
2
58.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mediator complex subunit 12
696791
Mouse
MGI:1926212
59024
Rat
RGD:1585896
679693
Dog
mediator complex subunit 12
VGNC:43120
100855688
Horse
mediator complex subunit 12
VGNC:20070
100056909
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mediator complex subunit 12
Mouse
Rat
Dog
mediator complex subunit 12
Horse
mediator complex subunit 12
Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999999067
p_ni: 9.33e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999998583
p_ni: 0.000001417
Score: 0.995
Data Source: BioPlex,STRINGDB
CCNC
Tbio
Novelty: 0.00585842
p_int: 0.999998141
p_ni: 0.000001859
Score: 0.999
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999997252
p_ni: 0.000002748
Score: 0.999
Data Source: BioPlex,STRINGDB
MED20
Tbio
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999995272
p_ni: 0.000004728
Score: 0.999
Data Source: BioPlex,STRINGDB
MED28
Tbio
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999990756
p_ni: 0.000009244
Score: 0.999
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999989107
p_ni: 0.000010893
Score: 0.999
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999987002
p_ni: 0.000012998
Score: 0.999
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.999980563
p_ni: 0.000019437
Score: 0.999
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.999966413
p_ni: 0.000033587
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  234.95

PubMed score by year
PubTator Score  167.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: