Tbio MED12 Mediator of RNA polymerase II transcription subunit 12

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• Q93074
• O15410
• O75557
• Q9UHV6
• Q9UND7

Gene Name

• MED12

Ensembl ID

• ENST00000374080
• ENSP00000363193
• ENSG00000184634
• ENST00000374102
• ENSP00000363215

Symbol

• ARC240
• CAGH45
• HOPA
• KIAA0192
• TNRC11
• TRAP230
• OKS
• FGS1
• HOPA
• OPA1
• OHDOX
• ARC240
• CAGH45
• MED12S
• TNRC11
• TRAP230

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.95
interacting protein	0.93
biological process	0.81
phenotype	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 12

Protein / Nucleic Acid Binding / Mediator Of Rna Polymerase Ii Transcription Subunit 12

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mediator Of Rna Polymerase Ii Transcription Subunit 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.18   (req: < 5)

Gene RIFs: 145   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.18   (req: >= 5)

Gene RIFs: 145   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0