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Tbio
ART4
Ecto-ADP-ribosyltransferase 4

Protein Summary
Description
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228936
  • ENSP00000228936
  • ENSG00000111339

Symbol
  • DO
  • DOK1
  • DO
  • DOK1
  • ARTC4
  • CD297
  • DO/ART4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.53
PubMedID
0.52
gene perturbation
0.5
metabolite
0.45
chemical
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.973209164
p_ni:  0.026790836
Data Source:  BioPlex
PIGU
Tbio
Novelty:  0.11800036
p_int:  0.973068191
p_ni:  0.026931752
p_wrong:  5.6e-8
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.961114712
p_ni:  0.038885285
p_wrong:  3e-9
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.959952564
p_ni:  0.040047435
Data Source:  BioPlex
GPM6A
Tbio
Novelty:  0.04123799
p_int:  0.861080407
p_ni:  0.018186015
p_wrong:  0.120733578
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.828466774
p_ni:  0.171533226
Data Source:  BioPlex
PIGS
Tdark
Family:  Enzyme
Novelty:  0.36443235
p_int:  0.757456427
p_ni:  0.242543573
Data Source:  BioPlex
ART3
Tbio
Family:  Enzyme
Novelty:  0.02783085
Score:  0.93
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.906
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
4
5
5
74.3
heel bone mineral density
2
1
2
67.7
BMI-adjusted hip circumference
1
1
1
21.5
osteoarthritis, hand
3
1
3
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
5
74.3
heel bone mineral density
2
67.7
BMI-adjusted hip circumference
1
21.5
osteoarthritis, hand
3
21.2
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosyltransferase 4
VGNC:4936
473376
Macaque
ADP-ribosyltransferase 4 (Dombrock blood group)
699934
Mouse
MGI:1202710
109978
Rat
RGD:1306456
312806
Dog
ADP-ribosyltransferase 4
VGNC:48874
486668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosyltransferase 4
Macaque
ADP-ribosyltransferase 4 (Dombrock blood group)
Mouse
Rat
Dog
ADP-ribosyltransferase 4
Publication Statistics
PubMed Score 6.80
PubMed score by year
PubTator Score 19.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title