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Tbio
EXT2
Exostosin-2

Protein Summary
Description
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343631
  • ENSP00000342656
  • ENSG00000151348
  • ENST00000358681
  • ENSP00000351509
  • ENST00000395673
  • ENSP00000379032
  • ENST00000533608
  • ENSP00000431173

Symbol
  • SOTV
  • SSMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.83
cellular component
0.8
virus perturbation
0.76
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.36   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.36   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (R-HSA-3656253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Reactome
Defective EXT2 causes exostoses 2
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective EXT2 causes exostoses 2
Disease
Diseases associated with glycosaminoglycan metabolism
Diseases of glycosylation
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
INVS
Tbio
Novelty: 0.00726865
p_int: 0.999988048
p_ni: 3.18e-7
p_wrong: 0.000011635
Score: 0.359
Data Source: BioPlex,STRINGDB
TTC19
Tbio
Novelty: 0.09680022
p_int: 0.999906537
p_ni: 0.000093443
p_wrong: 2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
RBFA
Tbio
Novelty: 0.12145749
p_int: 0.997134008
p_ni: 0.000025766
p_wrong: 0.002840226
Score: 0.163
Data Source: BioPlex,STRINGDB
EXT1
Tbio
Family: Enzyme
Novelty: 0.00234121
p_int: 0.995706036
p_ni: 0.004293964
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
AFAP1
Tbio
Novelty: 0.01138391
p_int: 0.991335525
p_ni: 2.7e-8
p_wrong: 0.008664448
Score: 0.359
Data Source: BioPlex,STRINGDB
ATE1
Tbio
Family: Enzyme
Novelty: 0.0119888
p_int: 0.988848392
p_ni: 0.011151608
Data Source: BioPlex
CUX1
Tbio
Novelty: 0.00305461
p_int: 0.984977607
p_ni: 0.015022393
Score: 0.221
Data Source: BioPlex,STRINGDB
USP30
Tbio
Family: Enzyme
Novelty: 0.0478459
p_int: 0.979750387
p_ni: 0.020249612
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
PSCA
Tbio
Novelty: 0.00370639
p_int: 0.93065173
p_ni: 0.06934827
Data Source: BioPlex
NOP9
Tdark
p_int: 0.898708476
p_ni: 0.101291403
p_wrong: 1.21e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  323.36

PubMed score by year
PubTator Score  136.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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