Tbio LPP Lipoma-preferred partner

Protein Summary

Description

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q93052
• A1L4L6
• D3DNV6
• Q8NFX5

Gene Name

• LPP

Ensembl ID

• ENST00000617246
• ENSP00000478901
• ENSG00000145012
• ENST00000640853
• ENSP00000491657

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
transcription factor perturbation	1
PubMedID	0.96
virus perturbation	0.96
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Lipoma-preferred Partner

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Lipoma-preferred Partner

Protein / Cell Junction Protein / Lipoma-preferred Partner

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Lipoma-preferred Partner

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.16   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.16   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0