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Tbio
ATP6V0A1
V-type proton ATPase 116 kDa subunit a isoform 1

Protein Summary
Description
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264649
  • ENSP00000264649
  • ENSG00000033627
  • ENST00000343619
  • ENSP00000342951
  • ENST00000393829
  • ENSP00000377415

Symbol
  • ATP6N1
  • ATP6N1A
  • VPP1
  • a1
  • Stv1
  • VPP1
  • Vph1
  • ATP6N1
  • ATP6N1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor binding site profile
0.94
biological process
0.93
disease perturbation
0.87
kinase perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a1
VGNC:9151
454685
Macaque
ATPase H+ transporting V0 subunit a1
677865
Mouse
MGI:103286
11975
Rat
RGD:68405
29757
Dog
ATPase H+ transporting V0 subunit a1
VGNC:38268
607705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V0 subunit a1
Macaque
ATPase H+ transporting V0 subunit a1
Mouse
Rat
Dog
ATPase H+ transporting V0 subunit a1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q93050-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (139)
1 – 10 of 139
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999989134
p_ni: 0.000010866
Score: 0.998
Data Source: BioPlex,STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
p_int: 0.999507931
p_ni: 0.000492069
Score: 0.997
Data Source: BioPlex,STRINGDB
KIAA2013
Tdark
Novelty: 0.4705158
p_int: 0.999221235
p_ni: 0.000778765
Score: 0.826
Data Source: BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
p_int: 0.999035882
p_ni: 0.000964117
Score: 0.852
Data Source: BioPlex,STRINGDB
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.999035339
p_ni: 0.000964661
Score: 0.97
Data Source: BioPlex,Reactome,STRINGDB
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.996882521
p_ni: 0.003117479
Data Source: BioPlex
BCAM
Tbio
Novelty: 0.01697541
p_int: 0.994972939
p_ni: 0.005027061
Data Source: BioPlex
MUC1
Tbio
Novelty: 0.00024203
p_int: 0.99486767
p_ni: 0.00513233
Score: 0.512
Data Source: BioPlex,STRINGDB
ATP6V0E1
Tbio
Family: Enzyme
Novelty: 0.076209
p_int: 0.984910771
p_ni: 0.015089229
Score: 0.987
Data Source: BioPlex,STRINGDB
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.982476698
p_ni: 0.017523302
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  51.42

PubMed score by year
PubTator Score  11.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer