Tbio ATP6V0A1 V-type proton ATPase 116 kDa subunit a isoform 1

Protein Summary

Description

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q93050
• B7Z3B7
• Q8N5G7
• Q9NSX0
• V-ATPase 116 kDa isoform a1

Gene Name

• ATP6V0A1

Ensembl ID

• ENST00000264649
• ENSP00000264649
• ENSG00000033627
• ENST00000343619
• ENSP00000342951
• ENST00000393829
• ENSP00000377415

Symbol

• ATP6N1
• ATP6N1A
• VPP1
• a1
• Stv1
• VPP1
• Vph1
• ATP6N1
• ATP6N1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor binding site profile	0.94
biological process	0.93
disease perturbation	0.87
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase 116 Kda Subunit A Isoform 1

Protein / Hydrolase / V-type Proton Atpase 116 Kda Subunit A Isoform 1

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase 116 Kda Subunit A Isoform 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.35   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.35   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0