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Tbio
STMN2
Stathmin-2

Protein Summary
Description
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220876
  • ENSP00000220876
  • ENSG00000104435
  • ENST00000518111
  • ENSP00000429243

Symbol
  • SCG10
  • SCGN10
  • SCG10
  • SCGN10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
PubMedID
0.85
gene perturbation
0.74
transcription factor perturbation
0.74
hub protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.31   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.31   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (146)
1 – 10 of 146
STMN3
Tbio
Novelty:  0.05061958
p_int:  0.999979448
p_ni:  0.0000049
p_wrong:  0.000015652
Score:  0.218
Data Source:  BioPlex,STRINGDB
ASRGL1
Tbio
Family:  Enzyme
Novelty:  0.02377734
p_int:  0.999927312
p_ni:  0.000072585
p_wrong:  1.02e-7
Data Source:  BioPlex
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999681154
p_ni:  0.000318846
Data Source:  BioPlex
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999446873
p_ni:  0.000553127
Data Source:  BioPlex
MBD3
Tbio
Family:  TF
Novelty:  0.04513502
p_int:  0.99865701
p_ni:  0.00134299
Data Source:  BioPlex
MBD2
Tchem
Family:  TF
Novelty:  0.01209635
p_int:  0.998325229
p_ni:  0.001661609
p_wrong:  0.000013162
Data Source:  BioPlex
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.996462443
p_ni:  0.003537556
p_wrong:  1e-9
Data Source:  BioPlex
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.99628451
p_ni:  0.00371549
Data Source:  BioPlex
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
p_int:  0.992279284
p_ni:  0.007720716
Data Source:  BioPlex
STMN1
Tbio
Novelty:  0.00117369
p_int:  0.989114607
p_ni:  0.010885393
Score:  0.561
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stathmin 2
VGNC:14595
464247
Macaque
stathmin 2
699264
Mouse
MGI:98241
20257
Rat
RGD:68947
84510
Dog
stathmin 2
VGNC:46926
477918
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stathmin 2
Macaque
stathmin 2
Mouse
Rat
Dog
stathmin 2
Publication Statistics
PubMed Score 121.31
PubMed score by year
PubTator Score 47.71
PubTator score by year