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Tbio
CUL5
Cullin-5

Protein Summary
Description
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393094
  • ENSP00000376808
  • ENSG00000166266
  • ENST00000531427
  • ENSP00000435376

Symbol
  • VACM1
  • CUL-5
  • VACM1
  • VACM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.88
interacting protein
0.86
molecular function
0.86
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.79   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.79   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (405)
1 – 10 of 405
ASB6
Tdark
Novelty:  0.32074223
p_int:  1
Score:  0.961
Data Source:  BioPlex,STRINGDB
WSB1
Tbio
Novelty:  0.04417716
p_int:  1
Score:  0.953
Data Source:  BioPlex,STRINGDB
SOCS6
Tbio
Novelty:  0.00993375
p_int:  0.999999999
p_ni:  1e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
TULP4
Tbio
Family:  TF
Novelty:  0.05658032
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
SOCS7
Tbio
Novelty:  0.01296916
p_int:  0.999999999
Score:  0.837
Data Source:  BioPlex,STRINGDB
LRRC28
Tdark
Novelty:  0.65377588
p_int:  0.999999998
p_ni:  2e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
RAB40B
Tbio
Novelty:  0.2288213
p_int:  0.999999997
p_ni:  3e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
ASB8
Tdark
Novelty:  0.44680949
p_int:  0.999999994
p_ni:  6e-9
Score:  0.93
Data Source:  BioPlex,STRINGDB
ASB1
Tdark
Novelty:  0.0931554
p_int:  0.999999991
p_ni:  5e-9
p_wrong:  4e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
SPSB2
Tbio
Novelty:  0.07223184
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
Pathways (21)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Disease
Reactome
Downregulation of ERBB2 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Disease
Downregulation of ERBB2 signaling
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
78
platelet crit
1
1
1
77.9
lymphocyte percentage of leukocytes
1
1
1
58.4
mosaic loss of chromosome Y measurement
1
1
1
46.1
platelet count
1
1
1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
78
platelet crit
1
77.9
lymphocyte percentage of leukocytes
1
58.4
mosaic loss of chromosome Y measurement
1
46.1
platelet count
1
32.7
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 5
VGNC:3137
466773
Macaque
cullin 5
707559
Mouse
MGI:1922967
75717
Rat
RGD:621742
64624
Dog
cullin 5
VGNC:39733
489422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 5
Macaque
cullin 5
Mouse
Rat
Dog
cullin 5
Publication Statistics
PubMed Score 125.79
PubMed score by year
PubTator Score 64.78
PubTator score by year