NAA80
N-alpha-acetyltransferase 80
Protein Summary
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. T ...more
- ENST00000354862
- ENSP00000346927
- ENSG00000243477
- ENST00000417393
- ENSP00000391893
- ENST00000443094
- ENSP00000410610
- ENST00000443842
- ENSP00000400559
- FUS2
- NAT6
- FUS2
- NAT6
- FUS-2
- HsNAAA80
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.9 | ||
transcription factor binding site profile | 0.72 | ||
kinase perturbation | 0.66 | ||
pathway | 0.64 | ||
small molecule perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (4)
PFN2
Novelty: 0.00605366
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
WikiPathways (14)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Metapathway biotransformation Phase I and II | ||||
WikiPathways | Metapathway biotransformation Phase I and II | ||||
WikiPathways | Metapathway biotransformation Phase I and II | ||||
WikiPathways | Metapathway biotransformation Phase I and II | ||||
WikiPathways | Metapathway biotransformation Phase I and II | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metapathway biotransformation Phase I and II | ||||
Metapathway biotransformation Phase I and II | ||||
Metapathway biotransformation Phase I and II | ||||
Metapathway biotransformation Phase I and II | ||||
Metapathway biotransformation Phase I and II | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 7 | 14 | 99.5 | |||||
reticulocyte count | 2 | 4 | 8 | 98.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 85.1 | |||||
chronotype measurement | 1 | 2 | 0 | 1 | 78.7 | ||||
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 66.2 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 14 | 99.5 | |||||
reticulocyte count | 8 | 98.7 | |||||
mean reticulocyte volume | 1 | 85.1 | |||||
chronotype measurement | 0 | 1 | 78.7 | ||||
macrophage inflammatory protein 1b measurement | 2 | 66.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | N-acetyltransferase 6 | 703022 | ||||||
Mouse | MGI:1888902 | 56441 | ||||||
Pig | N-acetyltransferase 6 | 445004 | ||||||
Opossum | N-acetyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:30252] | |||||||
Anole lizard | N-acetyltransferase 6 | 100563594 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | N-acetyltransferase 6 | |||||
Mouse | ||||||
Pig | N-acetyltransferase 6 | |||||
Opossum | N-acetyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:30252] | |||||
Anole lizard | N-acetyltransferase 6 | |||||
Publication Statistics
PubMed Score 1.23
PubMed score by year
PubTator Score 5.12
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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