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Tchem
USP7
Ubiquitin carboxyl-terminal hydrolase 7

Protein Summary
Description
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:26678539). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344836
  • ENSP00000343535
  • ENSG00000187555
  • ENST00000381886
  • ENSP00000371310

Symbol
  • HAUSP
  • TEF1
  • HAUSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
0.99
transcription factor perturbation
0.94
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.74   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 629   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.74   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 629   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
84.4
testosterone measurement
1
1
1
63.4
platelet count
2
2
2
57.2
lymphocyte count
2
1
2
51.9
chronotype measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.4
testosterone measurement
1
63.4
platelet count
2
57.2
lymphocyte count
2
51.9
chronotype measurement
1
42.3
Protein Data Bank (50)
1 – 5 of 50
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Name
Explore in Pharos
Explore in Source
DNA Repair
Deubiquitination
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (343)
1 – 10 of 343
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.99996849
p_ni: 0.00003151
Data Source: BioPlex
POTEC
Tdark
Novelty: 1.98957109
p_int: 0.999762202
p_ni: 0.000237798
Score: 0.533
Data Source: BioPlex,STRINGDB
DHX40
Tdark
Family: Enzyme
Novelty: 0.27906444
p_int: 0.999582913
p_ni: 0.000417087
Score: 0.173
Data Source: BioPlex,STRINGDB
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.993337761
p_ni: 0.006662239
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.989273085
p_ni: 0.010726915
Data Source: BioPlex
FAM170A
Tdark
Novelty: 0.05778712
p_int: 0.988681886
p_ni: 0.011318114
Data Source: BioPlex
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
p_int: 0.988632404
p_ni: 0.011367596
Score: 0.93
Data Source: BioPlex,STRINGDB
LCOR
Tbio
Family: TF
Novelty: 0.01638762
p_int: 0.98369989
p_ni: 0.01630011
Data Source: BioPlex
ZBTB44
Tdark
Family: TF
Novelty: 0.75195191
p_int: 0.979742477
p_ni: 0.020257523
Score: 0.208
Data Source: BioPlex,STRINGDB
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.976836131
p_ni: 0.023163869
Data Source: BioPlex
Publication Statistics
PubMed Score  275.74

PubMed score by year
PubTator Score  152

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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