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Tbio
USP9X
Probable ubiquitin carboxyl-terminal hydrolase FAF-X

Protein Summary
Description
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324545
  • ENSP00000316357
  • ENSG00000124486
  • ENST00000378308
  • ENSP00000367558

Symbol
  • DFFRX
  • FAM
  • USP9
  • FAF
  • FAM
  • DFFRX
  • MRX99
  • MRXS99F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
virus perturbation
0.98
kinase perturbation
0.96
microRNA
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.92   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.92   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
6
8
98
reticulocyte count
2
5
5
97.9
mean reticulocyte volume
1
1
1
31.3
red blood cell distribution width
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
8
98
reticulocyte count
5
97.9
mean reticulocyte volume
1
31.3
red blood cell distribution width
1
15.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 9, X-linked
106992260
Mouse
MGI:894681
22284
Rat
RGD:1560056
363445
Dog
ubiquitin specific peptidase 9, X-linked
480885
Horse
ubiquitin specific peptidase 9, X-linked
100050489
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 9, X-linked
Mouse
Rat
Dog
ubiquitin specific peptidase 9, X-linked
Horse
ubiquitin specific peptidase 9, X-linked
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q93008-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Deubiquitination
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Deubiquitination
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (192)
1 – 10 of 192
PEG10
Tbio
Novelty:  0.00478545
p_int:  0.998637883
p_ni:  0.001362117
Score:  0.513
Data Source:  BioPlex,STRINGDB
SUPV3L1
Tbio
Family:  Enzyme
Novelty:  0.01598799
p_int:  0.953991507
p_ni:  0.046008493
Score:  0.205
Data Source:  BioPlex,STRINGDB
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.953811491
p_ni:  0.046188509
Score:  0.163
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.938018159
p_ni:  0.061981841
Score:  0.209
Data Source:  BioPlex,STRINGDB
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.878446592
p_ni:  0.121553408
Score:  0.234
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.871959323
p_ni:  0.128040677
Score:  0.207
Data Source:  BioPlex,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.969
Data Source:  Reactome,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.967
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.959
Data Source:  STRINGDB
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
Score:  0.956
Data Source:  STRINGDB
Publication Statistics
PubMed Score  148.92

PubMed score by year
PubTator Score  99.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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