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Tbio
DVL3
Segment polarity protein dishevelled homolog DVL-3

Protein Classes
Protein Summary
Description
Involved in the signal transduction pathway mediated by multiple Wnt genes. This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313143
  • ENSP00000316054
  • ENSG00000161202
  • ENST00000431765
  • ENSP00000405885
  • ENST00000649964
  • ENSP00000497134

Symbol
  • KIAA0208
  • DRS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.84
microRNA
0.76
cell type or tissue
0.72
pathway
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.04   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.04   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
50.8
Pathways (52)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Degradation of DVL
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
PCP/CE pathway
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (234)
1 – 10 of 234
DVL2
Tbio
Novelty: 0.00833084
p_int: 0.999999401
p_ni: 4.63e-7
p_wrong: 1.36e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999998862
p_ni: 0.000001138
Score: 0.209
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999989687
p_ni: 0.00001029
p_wrong: 2.2e-8
Data Source: BioPlex
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.999951436
p_ni: 0.000048564
Score: 0.207
Data Source: BioPlex,STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
p_int: 0.999901145
p_ni: 0.000098855
Score: 0.966
Data Source: BioPlex,STRINGDB
CRNKL1
Tbio
Novelty: 0.10274174
p_int: 0.999251739
p_ni: 0.000748261
Score: 0.55
Data Source: BioPlex,STRINGDB
NXN
Tbio
Novelty: 0.00968089
p_int: 0.999085125
p_ni: 0.000914875
Score: 0.333
Data Source: BioPlex,STRINGDB
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.998701056
p_ni: 0.001298944
Score: 0.977
Data Source: BioPlex,STRINGDB
SYF2
Tbio
Novelty: 0.06114903
p_int: 0.998441203
p_ni: 0.001558797
Score: 0.74
Data Source: BioPlex,STRINGDB
AQR
Tbio
Novelty: 0.00434312
p_int: 0.996051254
p_ni: 0.003948746
Score: 0.529
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  58.04

PubMed score by year
PubTator Score  36.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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