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Tchem
USP13
Ubiquitin carboxyl-terminal hydrolase 13

Protein Summary
Description
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263966
  • ENSP00000263966
  • ENSG00000058056
  • ENST00000496897
  • ENSP00000417146

Symbol
  • ISOT3
  • ISOT3
  • IsoT-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
kinase perturbation
0.84
molecular function
0.84
disease perturbation
0.79
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.36   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.36   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2391504
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism of proteins
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Name
Explore in Pharos
Explore in Source
Deubiquitination
Intracellular signaling by second messengers
Metabolism of proteins
PIP3 activates AKT signaling
PTEN Regulation
Gene Ontology Terms (26)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Protein-Protein Interactions (135)
1 – 10 of 135
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.999999988
p_ni: 9e-9
p_wrong: 3e-9
Data Source: BioPlex
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.06603568
p_int: 0.999999628
p_ni: 4e-8
p_wrong: 3.32e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
REC8
Tbio
Novelty: 0.00732742
p_int: 0.999999115
p_ni: 8.5e-7
p_wrong: 3.5e-8
Data Source: BioPlex
RPP25
Tbio
Family: Enzyme
Novelty: 0.07178063
p_int: 0.999998658
p_ni: 1.5e-7
p_wrong: 0.000001192
Score: 0.248
Data Source: BioPlex,STRINGDB
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.999994595
p_ni: 4.7e-8
p_wrong: 0.000005359
Score: 0.188
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.982
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.979
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.973
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.971
Data Source: STRINGDB
USP10
Tchem
Family: Enzyme
Novelty: 0.05830541
Score: 0.967
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  33.36

PubMed score by year
PubTator Score  9.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer