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Tchem
KAT5
Histone acetyltransferase KAT5

Protein Summary
Description
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341318
  • ENSP00000340330
  • ENSG00000172977
  • ENST00000352980
  • ENSP00000344955
  • ENST00000377046
  • ENSP00000366245
  • ENST00000530446
  • ENSP00000434765

Symbol
  • HTATIP
  • TIP60
  • TIP
  • ESA1
  • PLIP
  • TIP60
  • cPLA2
  • HTATIP
  • ZC2HC5
  • HTATIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
biological process
0.97
molecular function
0.9
transcription factor binding site profile
0.85
histone modification site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.31   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.31   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
MG149
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
1
3
83.9
triglyceride measurement
1
1
1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
83.9
triglyceride measurement
1
19.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 5
VGNC:7650
451329
Macaque
lysine acetyltransferase 5
715880
Mouse
MGI:1932051
81601
Rat
RGD:621061
192218
Dog
lysine acetyltransferase 5
VGNC:42211
483728
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 5
Macaque
lysine acetyltransferase 5
Mouse
Rat
Dog
lysine acetyltransferase 5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (37)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (424)
1 – 10 of 424
MEAF6
Tbio
Novelty: 0.0914094
p_int: 1
Score: 0.996
Data Source: BioPlex,STRINGDB
FOXR2
Tbio
Family: TF
Novelty: 0.06548862
p_int: 0.999999798
p_ni: 2.02e-7
Score: 0.82
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.999999658
p_ni: 3.41e-7
p_wrong: 1e-9
Score: 0.727
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999999637
p_ni: 3.63e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.999999019
p_ni: 9.81e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999998939
p_ni: 0.000001061
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.999998513
p_ni: 0.000001487
Score: 0.991
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999990563
p_ni: 0.000009435
p_wrong: 2e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
EPC1
Tbio
Novelty: 0.03216371
p_int: 0.999988593
p_ni: 0.000011407
Score: 0.996
Data Source: BioPlex,STRINGDB
MRGBP
Tbio
Novelty: 0.09537142
p_int: 0.999977209
p_ni: 0.000022791
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  279.31

PubMed score by year
PubTator Score  194.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer