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Tchem
KAT5
Histone acetyltransferase KAT5

Protein Summary
Description
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repres ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341318
  • ENSP00000340330
  • ENSG00000172977
  • ENST00000352980
  • ENSP00000344955
  • ENST00000377046
  • ENSP00000366245
  • ENST00000530446
  • ENSP00000434765

Symbol
  • HTATIP
  • TIP60
  • TIP
  • ESA1
  • PLIP
  • TIP60
  • cPLA2
  • HTATIP
  • ZC2HC5
  • HTATIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
biological process
0.97
molecular function
0.9
transcription factor binding site profile
0.85
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.81   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.81   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0