Tbio KAT5 Histone acetyltransferase KAT5

Protein Summary

Description

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565). Acetylates RAN at 'Lys-134' (PubMed:29040603). The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92993
• B4E3C7
• C9JL99
• O95624
• Q13430
• Q17RW5
• Q561W3
• Q6GSE8
• Q9BWK7

Gene Name

• KAT5

Ensembl ID

• ENST00000341318
• ENSP00000340330
• ENSG00000172977
• ENST00000352980
• ENSP00000344955
• ENST00000377046
• ENSP00000366245
• ENST00000530446
• ENSP00000434765

Symbol

• HTATIP
• TIP60
• TIP
• ESA1
• PLIP
• TIP60
• cPLA2
• HTATIP
• ZC2HC5
• HTATIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
biological process	0.97
molecular function	0.9
transcription factor binding site profile	0.85
histone modification site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Histone Acetyltransferase Kat5

Protein / Transcription Factor / Zinc Finger Transcription Factor / Histone Acetyltransferase Kat5

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Acetyltransferase Kat5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.81   (req: < 5)

Gene RIFs: 172   (req: <= 3)

Antibodies: 650   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.81   (req: >= 5)

Gene RIFs: 172   (req: > 3)

Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0