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Tbio
IRF7
Interferon regulatory factor 7

Protein Summary
Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localiz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330243
  • ENSP00000329411
  • ENSG00000185507
  • ENST00000348655
  • ENSP00000331803
  • ENST00000397566
  • ENSP00000380697
  • ENST00000397574
  • ENSP00000380704
  • ENST00000469048
  • ENSP00000434607
  • ENST00000525445
  • ENSP00000434009
  • ENST00000533182
  • ENSP00000433903
  • ENST00000612534
  • ENSP00000479615
  • ENSG00000276561
  • ENST00000621391
  • ENSP00000480358
  • ENST00000632827
  • ENSP00000488039
  • ENST00000633274
  • ENSP00000488591
  • ENST00000633943
  • ENSP00000488666
  • ENST00000634105
  • ENSP00000488581

Symbol
  • IMD39
  • IRF-7
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • IRF-7H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.98
gene perturbation
0.91
protein domain
0.85
hub protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.27   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 558   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.27   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 558   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
85.7
2
2
0
1.2
85.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
85.7
0
1.2
85.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 7
VGNC:11843
450927
Macaque
interferon regulatory factor 7
699578
Mouse
MGI:1859212
54123
Rat
RGD:1307828
293624
Horse
interferon regulatory factor 7
VGNC:19137
100055087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 7
Macaque
interferon regulatory factor 7
Mouse
Rat
Horse
interferon regulatory factor 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92985-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Gene Ontology Terms (37)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (389)
1 – 10 of 389
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.996
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.995
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.995
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.995
Data Source: Reactome,STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.995
Data Source: STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.995
Data Source: Reactome,STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.994
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.993
Data Source: Reactome,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.993
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  435.27

PubMed score by year
PubTator Score  288.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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