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Tbio
IRF7
Interferon regulatory factor 7

Protein Summary
Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localiz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330243
  • ENSP00000329411
  • ENSG00000185507
  • ENST00000348655
  • ENSP00000331803
  • ENST00000397566
  • ENSP00000380697
  • ENST00000397574
  • ENSP00000380704
  • ENST00000469048
  • ENSP00000434607
  • ENST00000525445
  • ENSP00000434009
  • ENST00000533182
  • ENSP00000433903
  • ENST00000612534
  • ENSP00000479615
  • ENSG00000276561
  • ENST00000621391
  • ENSP00000480358
  • ENST00000632827
  • ENSP00000488039
  • ENST00000633274
  • ENSP00000488591
  • ENST00000633943
  • ENSP00000488666
  • ENST00000634105
  • ENSP00000488581

Symbol
  • IMD39
  • IRF-7
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • IRF-7H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.98
gene perturbation
0.91
protein domain
0.85
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.95   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 558   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.95   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 558   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0