Tbio NINJ1 Ninjurin-1

Protein Summary

Description

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

Uniprot Accession IDs

• Q92982
• Q6GU89
• Q8WUV5
• Q9BT07

Gene Name

• NINJ1

Ensembl ID

• ENST00000375446
• ENSP00000364595
• ENSG00000131669

Symbol

• NIN1
• NINJURIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.87
gene perturbation	0.84
transcription factor binding site profile	0.81
PubMedID	0.77

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Ninjurin-1

DTO Classes

Protein / Cell Adhesion / Ninjurin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.13   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.13   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0