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Tbio
NINJ1
Ninjurin-1

Protein Summary
Description
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations. The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375446
  • ENSP00000364595
  • ENSG00000131669

Symbol
  • NIN1
  • NINJURIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.87
gene perturbation
0.84
transcription factor binding site profile
0.81
PubMedID
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.7   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.7   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
L lactate dehydrogenase measurement
1
1
1
48.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
L lactate dehydrogenase measurement
1
48.6
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (12)
1 – 10 of 12
NOB1
Tbio
Novelty: 0.01209681
Score: 0.905
Data Source: STRINGDB
PSMD8
Tbio
Family: Enzyme
Novelty: 0.03053455
Score: 0.881
Data Source: STRINGDB
CATIP
Tdark
Novelty: 0.28211918
Score: 0.576
Data Source: STRINGDB
TSSC4
Tdark
Novelty: 0.17064786
Score: 0.532
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.53
Data Source: STRINGDB
WNT7B
Tbio
Novelty: 0.00684526
Score: 0.482
Data Source: STRINGDB
NIN
Tbio
Novelty: 0.01312714
Score: 0.47
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.452
Data Source: STRINGDB
ADAMTS6
Tbio
Family: Enzyme
Novelty: 0.08054942
Score: 0.435
Data Source: STRINGDB
FAM218A
Tdark
Novelty: 10.69354839
Score: 0.429
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.70

PubMed score by year
PubTator Score  32.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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