You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGEF2
Rho guanine nucleotide exchange factor 2

Protein Classes
Protein Summary
Description
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313667
  • ENSP00000314787
  • ENSG00000116584
  • ENST00000313695
  • ENSP00000315325
  • ENST00000361247
  • ENSP00000354837

Symbol
  • KIAA0651
  • LFP40
  • GEF
  • P40
  • GEFH1
  • LFP40
  • GEF-H1
  • NEDMHM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
1
interacting protein
1
protein complex
1
transcription factor perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.42   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.42   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
5
89
body height
1
1
1
71.6
serum gamma-glutamyl transferase measurement
1
3
3
68.3
urate measurement
1
2
2
61.8
sex hormone-binding globulin measurement
2
1
2
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
89
body height
1
71.6
serum gamma-glutamyl transferase measurement
3
68.3
urate measurement
2
61.8
sex hormone-binding globulin measurement
2
61
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho/Rac guanine nucleotide exchange factor 2
VGNC:6721
457378
Macaque
Rho/Rac guanine nucleotide exchange factor 2
719369
Mouse
MGI:103264
16800
Rat
RGD:1304659
310635
Dog
Rho/Rac guanine nucleotide exchange factor 2
VGNC:38080
403498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho/Rac guanine nucleotide exchange factor 2
Macaque
Rho/Rac guanine nucleotide exchange factor 2
Mouse
Rat
Dog
Rho/Rac guanine nucleotide exchange factor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92974-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Gene Ontology Terms (53)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (120)
1 – 10 of 120
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.99999947
p_ni:  5.29e-7
p_wrong:  1e-9
Data Source:  BioPlex
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.999997535
p_ni:  0.000002465
Score:  0.489
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.999951086
p_ni:  0.000048909
p_wrong:  6e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999927515
p_ni:  0.000072434
p_wrong:  5.1e-8
Score:  0.155
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999915686
p_ni:  0.000084306
p_wrong:  8e-9
Score:  0.371
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
CGN
Tbio
Novelty:  0.01097394
Score:  0.973
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.968
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.966
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.963
Data Source:  STRINGDB
Publication Statistics
PubMed Score  82.42

PubMed score by year
PubTator Score  365.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: