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Tbio
TNPO1
Transportin-1

Protein Summary
Description
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337273
  • ENSP00000336712
  • ENSG00000083312
  • ENST00000506351
  • ENSP00000425118
  • ENST00000523768
  • ENSP00000428899

Symbol
  • KPNB2
  • MIP1
  • TRN
  • MIP
  • TRN
  • IPO2
  • MIP1
  • KPNB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
viral protein
0.98
virus perturbation
0.94
microRNA
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.14   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.14   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (240)
SIGLECL1
Tdark
p_int:  0.950108326
p_ni:  0.049891674
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.939726595
p_ni:  0.060273405
Score:  0.19
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.894770571
p_ni:  0.105229429
Score:  0.188
Data Source:  BioPlex,STRINGDB
TRARG1
Tbio
Novelty:  0.07729433
p_int:  0.846854256
p_ni:  0.153145744
Score:  0.309
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.765543058
p_ni:  0.234456942
Data Source:  BioPlex
FUS
Tbio
Novelty:  0.00065625
Score:  0.987
Data Source:  STRINGDB
HNRNPD
Tbio
Novelty:  0.00538829
Score:  0.985
Data Source:  STRINGDB
NXF1
Tbio
Novelty:  0.00642439
Score:  0.983
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.981
Data Source:  STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Metabolism of RNA
Reactome
Organelle biogenesis and maintenance
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Metabolism of RNA
Organelle biogenesis and maintenance
Regulation of mRNA stability by proteins that bind AU-rich elements
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
95.5
platelet count
2
3
3
89.5
mean corpuscular hemoglobin concentration
3
3
3
85
mean platelet volume
3
1
3
84.3
albumin:globulin ratio measurement
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
95.5
platelet count
3
89.5
mean corpuscular hemoglobin concentration
3
85
mean platelet volume
3
84.3
albumin:globulin ratio measurement
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transportin 1
VGNC:4207
461817
Macaque
transportin 1
707195
Mouse
MGI:2681523
238799
Rat
RGD:1308372
309126
Dog
transportin 1
VGNC:47694
478093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transportin 1
Macaque
transportin 1
Mouse
Rat
Dog
transportin 1
Publication Statistics
PubMed Score 64.14
PubMed score by year
PubTator Score 70.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title