Tbio SNAPC3 snRNA-activating protein complex subunit 3

Protein Summary

Description

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Uniprot Accession IDs

• Q92966
• D3DRI8
• Q2VPI6
• Q5T285
• SNAPc subunit 3

Gene Name

• SNAPC3

Ensembl ID

• ENST00000380821
• ENSP00000370200
• ENSG00000164975
• ENST00000467062
• ENSP00000436699
• ENST00000490969
• ENSP00000432393
• ENST00000610884
• ENSP00000483273

Symbol

• SNAP50
• SNAP50
• PTFbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.87
histone modification site profile	0.75
PubMedID	0.72
kinase perturbation	0.71
tissue sample	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0