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Tbio
RIT1
GTP-binding protein Rit1

Protein Summary
Description
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368322
  • ENSP00000357305
  • ENSG00000143622
  • ENST00000368323
  • ENSP00000357306
  • ENST00000539040
  • ENSP00000441950

Symbol
  • RIBB
  • RIT
  • ROC1
  • NS8
  • RIT
  • RIBB
  • ROC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.96
virus perturbation
0.96
kinase perturbation
0.88
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
1 – 10 of 53
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.99999777
p_ni:  0.000002147
p_wrong:  8.3e-8
Score:  0.806
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999948525
p_ni:  0.000051475
Score:  0.27
Data Source:  BioPlex,STRINGDB
RIT2
Tbio
Family:  Enzyme
Novelty:  0.01672192
p_int:  0.999005573
p_ni:  0.000004359
p_wrong:  0.000990068
Score:  0.988
Data Source:  BioPlex,STRINGDB
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.998435766
p_ni:  0.001560574
p_wrong:  0.00000366
Score:  0.199
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
Score:  0.944
Data Source:  Reactome,STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.927
Data Source:  Reactome,STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.926
Data Source:  Reactome,STRINGDB
NTRK2
Tclin
Family:  Kinase
Novelty:  0.00054534
Score:  0.922
Data Source:  STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
Score:  0.916
Data Source:  STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.91
Data Source:  STRINGDB
Pathways (11)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signalling to ERKs
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Signaling by Receptor Tyrosine Kinases
Signalling to ERKs
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
3
3
68.3
sex hormone-binding globulin measurement
2
1
2
61
birth weight
1
1
1
51.7
body mass index
1
2
2
48.4
1
1
0
1.1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
68.3
sex hormone-binding globulin measurement
2
61
birth weight
1
51.7
body mass index
2
48.4
0
1.1
46.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras like without CAAX 1
VGNC:10428
457377
Macaque
Ras like without CAAX 1
717985
Mouse
MGI:108053
19769
Rat
RGD:1559874
499652
Dog
Ras like without CAAX 1
VGNC:45600
480126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras like without CAAX 1
Macaque
Ras like without CAAX 1
Mouse
Rat
Dog
Ras like without CAAX 1
Publication Statistics
PubMed Score 41.23
PubMed score by year
PubTator Score 44.32
PubTator score by year