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Tchem
SLCO2A1
Solute carrier organic anion transporter family member 2A1

Protein Classes
Protein Summary
Description
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310926
  • ENSP00000311291
  • ENSG00000174640

Symbol
  • OATP2A1
  • SLC21A2
  • PGT
  • MATR1
  • PHOAR2
  • OATP2A1
  • SLC21A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
transcription factor perturbation
0.91
PubMedID
0.84
tissue sample
0.71
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.06   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.06   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (R-HSA-5619095)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Protein-Protein Interactions (41)
1 – 10 of 41
HPGD
Tchem
Family: Enzyme
Novelty: 0.00408699
Score: 0.738
Data Source: STRINGDB
SLC7A13
Tdark
Family: Transporter
Novelty: 0.1422516
Score: 0.672
Data Source: STRINGDB
ABCC4
Tchem
Family: Transporter
Novelty: 0.00256244
Score: 0.652
Data Source: STRINGDB
PTGFR
Tclin
Family: GPCR
Novelty: 0.00739575
Score: 0.616
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.0011862
Score: 0.585
Data Source: STRINGDB
ARL6IP4
Tbio
Novelty: 0.02683277
Score: 0.579
Data Source: STRINGDB
PTGER2
Tclin
Family: GPCR
Novelty: 0.02221942
Score: 0.576
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01776292
Score: 0.574
Data Source: STRINGDB
PTGER4
Tclin
Family: GPCR
Novelty: 0.00101275
Score: 0.573
Data Source: STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00263045
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  408.06

PubMed score by year
PubTator Score  70

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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