Tchem SLCO2A1 Solute carrier organic anion transporter family member 2A1

Protein Summary

Description

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q92959
• Q86V98
• Q8IUN2

Gene Name

• SLCO2A1

Ensembl ID

• ENST00000310926
• ENSP00000311291
• ENSG00000174640

Symbol

• OATP2A1
• SLC21A2
• PGT
• MATR1
• PHOAR2
• OATP2A1
• SLC21A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
transcription factor perturbation	0.91
PubMedID	0.84
tissue sample	0.71
cell type or tissue	0.7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.56   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.56   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

dinoprost

SLCO2A1Tchem Transporter

pKi : 7.64

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

Prostaglandin D2

SLCO2A1Tchem Transporter

pKi : 7.42

Latonoprost acid

SLCO2A1Tchem Transporter

pKi : 6.83

bromsulphthalein

SLCO2A1Tchem Transporter

pKi : 5.24

bromocresol green

SLCO2A1Tchem Transporter

pKi : 5.44

Protein-Protein Interactions (41)

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1 – 10 of 41

• See Interactions on String-DB

HPGD

Tchem

Family:  Enzyme

Novelty:  0.00348376

Score:  0.738

Data Source:  STRINGDB

SLC7A13

Tdark

Family:  Transporter

Novelty:  0.20907223

Score:  0.672

Data Source:  STRINGDB

ABCC4

Tchem

Family:  Transporter

Novelty:  0.00208051

Score:  0.652

Data Source:  STRINGDB

PTGFR

Tclin

Family:  GPCR

Novelty:  0.00560908

Score:  0.616

Data Source:  STRINGDB

PTGES

Tchem

Family:  Enzyme

Novelty:  0.00146096

Score:  0.585

Data Source:  STRINGDB

ARL6IP4

Tbio

Novelty:  0.01317084

Score:  0.579

Data Source:  STRINGDB

PTGER2

Tclin

Family:  GPCR

Novelty:  0.0206174

Score:  0.576

Data Source:  STRINGDB

SLC22A11

Tclin

Family:  Transporter

Novelty:  0.01343595

Score:  0.574

Data Source:  STRINGDB

PTGER4

Tclin

Family:  GPCR

Novelty:  0.0008127

Score:  0.573

Data Source:  STRINGDB

BBOX1

Tchem

Family:  Enzyme

Novelty:  0.00255489

Score:  0.549

Data Source:  STRINGDB

Pathways (8)

Reactome (8)

Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (R-HSA-5619095)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	1 targets	R-HSA-5619095
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Reactome	SLC transporter disorders	100 targets	R-HSA-5619102
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Name	Explore in Pharos	Explore in Source
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	1 targets	R-HSA-5619095
Disease	1105 targets	R-HSA-1643685
Disorders of transmembrane transporters	178 targets	R-HSA-5619115
SLC transporter disorders	100 targets	R-HSA-5619102
SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Gene Ontology Terms (9)

Functions (3)

Components (3)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
prostaglandin transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sodium-independent organic anion transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipid transporter activity	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	3	3	0	1.1	77.1
body height	EFO_0004339	1	1	1		65.9
mean reticulocyte volume	EFO_0010701	1	1	1		54.4
testosterone measurement	EFO_0004908	1	1	1		46.5
colorectal adenoma	EFO_0005406	1	1	0	1.1	30.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	0	1.1	77.1
body height	EFO_0004339	1		65.9
mean reticulocyte volume	EFO_0010701	1		54.4
testosterone measurement	EFO_0004908	1		46.5
colorectal adenoma	EFO_0005406	0	1.1	30.2

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UniProt Keyword Find Similar Targets

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3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

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body height
cognitive function measurement
colorectal adenoma
colorectal cancer
mean reticulocyte volume
self reported educational attainment
testosterone measurement

MGI Phenotype Find Similar Targets

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cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 2A1	VGNC:8012	460711
Macaque	solute carrier organic anion transporter family member 2A1		717411
Mouse	solute carrier organic anion transporter family, member 2a1	MGI:1346021	24059
Rat	solute carrier organic anion transporter family, member 2a1	RGD:3051	24546
Dog	solute carrier organic anion transporter family member 2A1	VGNC:46495	485668

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 2A1
Macaque	solute carrier organic anion transporter family member 2A1
Mouse	solute carrier organic anion transporter family, member 2a1
Rat	solute carrier organic anion transporter family, member 2a1
Dog	solute carrier organic anion transporter family member 2A1

Publication Statistics

PubMed Score 862.56

PubMed score by year

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PubTator Score 70.00

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