SLCO2A1
Solute carrier organic anion transporter family member 2A1
Protein Summary
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
- ENST00000310926
- ENSP00000311291
- ENSG00000174640
- OATP2A1
- SLC21A2
- PGT
- MATR1
- PHOAR2
- OATP2A1
- SLC21A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
transcription factor perturbation | 0.91 | ||
PubMedID | 0.84 | ||
tissue sample | 0.71 | ||
cell type or tissue | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.56 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 59 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.56 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 59 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (4)
Protein-Protein Interactions (41)
Nearest Tclin Targets
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | SLC transporter disorders | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
SLC transporter disorders | ||||
SLC-mediated transmembrane transport | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1.1 | 77.1 | |||||
body height | 1 | 1 | 1 | 65.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 54.4 | |||||
testosterone measurement | 1 | 1 | 1 | 46.5 | |||||
1 | 1 | 0 | 1.1 | 30.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 77.1 | |||||
body height | 1 | 65.9 | |||||
mean reticulocyte volume | 1 | 54.4 | |||||
testosterone measurement | 1 | 46.5 | |||||
0 | 1.1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier organic anion transporter family member 2A1 | VGNC:8012 | 460711 | |||||
Macaque | solute carrier organic anion transporter family member 2A1 | 717411 | ||||||
Mouse | MGI:1346021 | 24059 | ||||||
Rat | RGD:3051 | 24546 | ||||||
Dog | solute carrier organic anion transporter family member 2A1 | VGNC:46495 | 485668 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier organic anion transporter family member 2A1 | |||||
Macaque | solute carrier organic anion transporter family member 2A1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier organic anion transporter family member 2A1 | |||||
Publication Statistics
PubMed Score 862.56
PubMed score by year
PubTator Score 70.00
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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