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Tchem
SLCO2A1
Solute carrier organic anion transporter family member 2A1

Protein Summary
Description
May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310926
  • ENSP00000311291
  • ENSG00000174640

Symbol
  • OATP2A1
  • SLC21A2
  • PGT
  • MATR1
  • PHOAR2
  • OATP2A1
  • SLC21A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
transcription factor perturbation
0.91
PubMedID
0.84
tissue sample
0.71
cell type or tissue
0.7


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.85   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.85   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
84.1
1
1
0
1.1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
84.1
0
1.1
36
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 2A1
VGNC:8012
460711
Macaque
solute carrier organic anion transporter family member 2A1
717411
Mouse
MGI:1346021
24059
Rat
RGD:3051
24546
Dog
solute carrier organic anion transporter family member 2A1
VGNC:46495
485668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 2A1
Macaque
solute carrier organic anion transporter family member 2A1
Mouse
Rat
Dog
solute carrier organic anion transporter family member 2A1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92959-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (R-HSA-5619095)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Protein-Protein Interactions (41)
1 – 10 of 41
HPGD
Tchem
Family: Enzyme
Novelty: 0.00348376
Score: 0.738
Data Source: STRINGDB
SLC7A13
Tdark
Family: Transporter
Novelty: 0.20907223
Score: 0.672
Data Source: STRINGDB
ABCC4
Tchem
Family: Transporter
Novelty: 0.00208051
Score: 0.652
Data Source: STRINGDB
PTGFR
Tclin
Family: GPCR
Novelty: 0.00560908
Score: 0.616
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.00146096
Score: 0.585
Data Source: STRINGDB
ARL6IP4
Tbio
Novelty: 0.01317084
Score: 0.579
Data Source: STRINGDB
PTGER2
Tclin
Family: GPCR
Novelty: 0.0206174
Score: 0.576
Data Source: STRINGDB
SLC22A11
Tclin
Family: Transporter
Novelty: 0.01343595
Score: 0.574
Data Source: STRINGDB
PTGER4
Tclin
Family: GPCR
Novelty: 0.0008127
Score: 0.573
Data Source: STRINGDB
BBOX1
Tchem
Family: Enzyme
Novelty: 0.00255489
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  789.85

PubMed score by year
PubTator Score  70

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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