Tchem SLCO2A1 Solute carrier organic anion transporter family member 2A1

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 2A1

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 2A1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 2A1

Protein Summary

Description

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q92959
• Q86V98
• Q8IUN2

Gene Name

• SLCO2A1

Ensembl ID

• ENST00000310926
• ENSP00000311291
• ENSG00000174640

Symbol

• OATP2A1
• SLC21A2
• PGT
• MATR1
• PHOAR2
• OATP2A1
• SLC21A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
transcription factor perturbation	0.91
PubMedID	0.84
tissue sample	0.71
cell type or tissue	0.7

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.85   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.85   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

bromocresol green

SLCO2A1Tchem Transporter

Ki : 5.44000006

bromsulphthalein

SLCO2A1Tchem Transporter

Ki : 5.23999977

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	3	3	0	1.1	84.1
colorectal adenoma	EFO_0005406	1	1	0	1.1	36

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	0	1.1	84.1
colorectal adenoma	EFO_0005406	0	1.1	36

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 2A1	VGNC:8012	460711
Macaque	solute carrier organic anion transporter family member 2A1		717411
Mouse	solute carrier organic anion transporter family, member 2a1	MGI:1346021	24059
Rat	solute carrier organic anion transporter family, member 2a1	RGD:3051	24546
Dog	solute carrier organic anion transporter family member 2A1	VGNC:46495	485668

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 2A1
Macaque	solute carrier organic anion transporter family member 2A1
Mouse	solute carrier organic anion transporter family, member 2a1
Rat	solute carrier organic anion transporter family, member 2a1
Dog	solute carrier organic anion transporter family member 2A1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92959-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (8)

Reactome (8)

Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) (R-HSA-5619095)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	1 targets	R-HSA-5619095
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Reactome	SLC transporter disorders	100 targets	R-HSA-5619102
Reactome	SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Name	Explore in Pharos	Explore in Source
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	1 targets	R-HSA-5619095
Disease	1105 targets	R-HSA-1643685
Disorders of transmembrane transporters	178 targets	R-HSA-5619115
SLC transporter disorders	100 targets	R-HSA-5619102
SLC-mediated transmembrane transport	250 targets	R-HSA-425407

Gene Ontology Terms (9)

Functions (3)

Components (3)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
prostaglandin transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sodium-independent organic anion transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipid transporter activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

HPGD

Tchem

Family: Enzyme

Novelty: 0.00348376

Score: 0.738

Data Source: STRINGDB

SLC7A13

Tdark

Family: Transporter

Novelty: 0.20907223

Score: 0.672

Data Source: STRINGDB

ABCC4

Tchem

Family: Transporter

Novelty: 0.00208051

Score: 0.652

Data Source: STRINGDB

PTGFR

Tclin

Family: GPCR

Novelty: 0.00560908

Score: 0.616

Data Source: STRINGDB

PTGES

Tchem

Family: Enzyme

Novelty: 0.00146096

Score: 0.585

Data Source: STRINGDB

ARL6IP4

Tbio

Novelty: 0.01317084

Score: 0.579

Data Source: STRINGDB

PTGER2

Tclin

Family: GPCR

Novelty: 0.0206174

Score: 0.576

Data Source: STRINGDB

SLC22A11

Tclin

Family: Transporter

Novelty: 0.01343595

Score: 0.574

Data Source: STRINGDB

PTGER4

Tclin

Family: GPCR

Novelty: 0.0008127

Score: 0.573

Data Source: STRINGDB

BBOX1

Tchem

Family: Enzyme

Novelty: 0.00255489

Score: 0.549

Data Source: STRINGDB

Publication Statistics

PubMed Score  789.85

PubMed score by year

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PubTator Score  70

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

colorectal adenoma
colorectal cancer

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype