Tbio TNFRSF14 Tumor necrosis factor receptor superfamily member 14

Protein Summary

Description

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q92956
• B3KW30
• B9DI89
• Q6IB95
• Q8N634
• Q8WXR1
• Q96J31
• Q9UM65

Gene Name

• TNFRSF14

Ensembl ID

• ENST00000355716
• ENSP00000347948
• ENSG00000157873
• ENST00000621877
• ENSP00000478308
• ENSG00000273936

Symbol

• HVEA
• HVEM
• TR2
• ATAR
• HVEA
• HVEM
• CD270
• LIGHTR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
biological process	0.93
gene perturbation	0.76
ligand (protein)	0.68
transcription factor	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.41   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 705   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.41   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 705   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0