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Tbio
TNFRSF14
Tumor necrosis factor receptor superfamily member 14

Protein Summary
Description
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2. This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355716
  • ENSP00000347948
  • ENSG00000157873
  • ENST00000621877
  • ENSP00000478308
  • ENSG00000273936

Symbol
  • HVEA
  • HVEM
  • TR2
  • ATAR
  • HVEA
  • HVEM
  • CD270
  • LIGHTR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
biological process
0.93
gene perturbation
0.76
ligand (protein)
0.68
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.59   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 705   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.59   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 705   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
59.8
eosinophil count
2
1
2
59.8
autoimmune thyroid disease
1
1
0
1.1
45
autoimmune thyroid disease
1
1
0
1.1
45
eosinophil percentage of leukocytes
1
1
1
22.3
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
59.8
eosinophil count
2
59.8
autoimmune thyroid disease
0
1.1
45
autoimmune thyroid disease
0
1.1
45
eosinophil percentage of leukocytes
1
22.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 14
VGNC:11936
457221
Macaque
TNF receptor superfamily member 14
695042
Mouse
MGI:2675303
230979
Rat
RGD:1310115
366518
Dog
TNF receptor superfamily member 14
VGNC:47658
479580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 14
Macaque
TNF receptor superfamily member 14
Mouse
Rat
Dog
TNF receptor superfamily member 14
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92956-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
Protein-Protein Interactions (78)
1 – 10 of 78
BTLA
Tbio
Novelty: 0.00770048
Score: 0.999
Data Source: Reactome,STRINGDB
TNFSF14
Tbio
Novelty: 0.01370893
Score: 0.995
Data Source: STRINGDB
LTA
Tbio
Novelty: 0.00100413
Score: 0.978
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.957
Data Source: Reactome,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.943
Data Source: STRINGDB
TRAF5
Tbio
Novelty: 0.01238512
Score: 0.933
Data Source: STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.929
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.921
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.921
Data Source: STRINGDB
CD160
Tbio
Novelty: 0.01511748
Score: 0.892
Data Source: STRINGDB
Publication Statistics
PubMed Score  352.59

PubMed score by year
PubTator Score  199.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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