You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRG4
Proteoglycan 4

Protein Summary
Description
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367483
  • ENSP00000356453
  • ENSG00000116690
  • ENST00000367485
  • ENSP00000356455
  • ENST00000445192
  • ENSP00000399679
  • ENST00000635041
  • ENSP00000489292

Symbol
  • MSF
  • SZP
  • MSF
  • SZP
  • CACP
  • HAPO
  • JCAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
protein domain
0.73
interacting protein
0.67
PubMedID
0.54
biological term
0.53


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.43   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.43   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891344
96875
Rat
RGD:1308976
289104
Dog
proteoglycan 4
VGNC:53626
664716
Cow
proteoglycan 4
VGNC:33314
280867
Pig
proteoglycan 4
100518683
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proteoglycan 4
Cow
proteoglycan 4
Pig
proteoglycan 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92954-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (41)
1 – 10 of 41
ACAN
Tbio
Novelty:  0.00033695
Score:  0.757
Data Source:  STRINGDB
HPX
Tbio
Novelty:  0.00138137
Score:  0.725
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.646
Data Source:  STRINGDB
MATN1
Tbio
Novelty:  0.00337153
Score:  0.61
Data Source:  STRINGDB
COMP
Tbio
Novelty:  0.00139358
Score:  0.601
Data Source:  STRINGDB
CSPG4
Tbio
Novelty:  0.0038499
Score:  0.59
Data Source:  STRINGDB
GLS2
Tchem
Family:  Enzyme
Novelty:  0.00284878
Score:  0.584
Data Source:  STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
Score:  0.573
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.562
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.559
Data Source:  STRINGDB
Publication Statistics
PubMed Score  474.43

PubMed score by year
PubTator Score  296.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer