You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
KCNB2
Potassium voltage-gated channel subfamily B member 2

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523207
  • ENSP00000430846
  • ENSG00000182674

Symbol
  • KV2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.79
trait
0.75
cell line
0.62
cell type or tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
77.5
visceral adipose tissue measurement
1
1
1
57.8
body fat percentage
1
1
1
39.6
body height
1
1
1
24.4
telomere length
1
1
1
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
77.5
visceral adipose tissue measurement
1
57.8
body fat percentage
1
39.6
body height
1
24.4
telomere length
1
24.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily B member 2
VGNC:12295
472792
Macaque
potassium voltage-gated channel subfamily B member 2
695006
Mouse
MGI:99632
98741
Cow
potassium voltage-gated channel subfamily B member 2
VGNC:30431
535990
Pig
potassium voltage-gated channel subfamily B member 2 [Source:HGNC Symbol;Acc:HGNC:6232]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily B member 2
Macaque
potassium voltage-gated channel subfamily B member 2
Mouse
Cow
potassium voltage-gated channel subfamily B member 2
Pig
potassium voltage-gated channel subfamily B member 2 [Source:HGNC Symbol;Acc:HGNC:6232]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92953-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (113)
1 – 10 of 113
KCNG4
Tclin
Family:  IC
Novelty:  0.07920772
p_int:  0.999989269
p_ni:  2.05e-7
p_wrong:  0.000010526
Score:  0.355
Data Source:  BioPlex,STRINGDB
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.99704674
p_ni:  9.8e-8
p_wrong:  0.002953162
Score:  0.299
Data Source:  BioPlex,STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.979
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.959
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.958
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.656
Data Source:  STRINGDB
KCNJ14
Tchem
Family:  IC
Novelty:  0.05707639
Score:  0.536
Data Source:  STRINGDB
CA4
Tclin
Family:  Enzyme
Novelty:  0.0004916
Score:  0.527
Data Source:  STRINGDB
Publication Statistics
PubMed Score  38.28

PubMed score by year
PubTator Score  15.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: