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Tbio
GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222214
  • ENSP00000222214
  • ENSG00000105607
  • ENST00000591470
  • ENSP00000466845

Symbol
  • GCD
  • ACAD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor perturbation
0.8
cell type or tissue
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.74   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.74   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
86.8
blood metabolite measurement
1
1
1
78.3
erythrocyte measurement
1
1
1
77.5
red blood cell distribution width
1
1
1
54.3
reticulocyte measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
86.8
blood metabolite measurement
1
78.3
erythrocyte measurement
1
77.5
red blood cell distribution width
1
54.3
reticulocyte measurement
1
46.1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaryl-CoA dehydrogenase
VGNC:11116
455754
Macaque
glutaryl-CoA dehydrogenase
716935
Mouse
MGI:104541
270076
Rat
RGD:1308829
364975
Dog
glutaryl-CoA dehydrogenase
VGNC:41141
476696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaryl-CoA dehydrogenase
Macaque
glutaryl-CoA dehydrogenase
Mouse
Rat
Dog
glutaryl-CoA dehydrogenase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92947-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (65)
1 – 10 of 65
ISCA1
Tbio
Novelty: 0.01288069
p_int: 0.961145986
p_ni: 0.038589105
p_wrong: 0.000264909
Score: 0.266
Data Source: BioPlex,STRINGDB
MARS2
Tbio
Family: Enzyme
Novelty: 0.02533315
p_int: 0.940274985
p_ni: 0.038393654
p_wrong: 0.021331361
Score: 0.522
Data Source: BioPlex,STRINGDB
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01291476
Score: 0.965
Data Source: STRINGDB
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.948
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00385746
Score: 0.946
Data Source: STRINGDB
ACADSB
Tbio
Family: Enzyme
Novelty: 0.02897344
Score: 0.944
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00878193
Score: 0.942
Data Source: STRINGDB
ACOX3
Tbio
Family: Enzyme
Novelty: 0.04077258
Score: 0.941
Data Source: STRINGDB
ACADM
Tbio
Family: Enzyme
Novelty: 0.00548721
Score: 0.93
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  247.74

PubMed score by year
PubTator Score  185.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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