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Tbio
KHSRP
Far upstream element-binding protein 2

Protein Summary
Description
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398148
  • ENSP00000381216
  • ENSG00000088247

Symbol
  • FUBP2
  • p75
  • FBP2
  • KSRP
  • FUBP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.92
co-expressed gene
0.82
transcription factor binding site profile
0.82
hub protein
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.59   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.59   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.999
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.979
Data Source:  Reactome,STRINGDB
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
Score:  0.976
Data Source:  Reactome,STRINGDB
CPSF6
Tbio
Novelty:  0.01263178
Score:  0.973
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.959
Data Source:  Reactome,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
Score:  0.952
Data Source:  STRINGDB
KHDRBS1
Tbio
Novelty:  0.00647929
Score:  0.951
Data Source:  STRINGDB
ELAVL1
Tchem
Novelty:  0.00110045
Score:  0.936
Data Source:  STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
Score:  0.932
Data Source:  Reactome,STRINGDB
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
KSRP (KHSRP) binds and destabilizes mRNA
Metabolism of RNA
Metabolism of proteins
PERK regulates gene expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KH-type splicing regulatory protein
VGNC:3629
455640
Macaque
KH-type splicing regulatory protein
702544
Mouse
MGI:1336214
16549
Rat
RGD:621828
171137
Dog
KH-type splicing regulatory protein
VGNC:42340
485022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KH-type splicing regulatory protein
Macaque
KH-type splicing regulatory protein
Mouse
Rat
Dog
KH-type splicing regulatory protein
Publication Statistics
PubMed Score 103.59
PubMed score by year
PubTator Score 68.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title