Tbio KHSRP Far upstream element-binding protein 2

Protein Summary

Description

Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• Q92945
• O00301
• Q59EZ9
• Q5U4P6
• Q9UNT5
• Q9UQH5
• FUSE-binding protein 2

Gene Name

• KHSRP

Ensembl ID

• ENST00000398148
• ENSP00000381216
• ENSG00000088247

Symbol

• FUBP2
• p75
• FBP2
• KSRP
• FUBP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	0.92
co-expressed gene	0.82
transcription factor binding site profile	0.82
hub protein	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Far Upstream Element-binding Protein 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Far Upstream Element-binding Protein 2

Protein / Enzyme Modulator / Far Upstream Element-binding Protein 2

Protein / ... / Serine Protease / Far Upstream Element-binding Protein 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Far Upstream Element-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.3   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.3   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0