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Tchem
BAD
Bcl2-associated agonist of cell death

Protein Summary
Description
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309032
  • ENSP00000309103
  • ENSG00000002330
  • ENST00000394532
  • ENSP00000378040

Symbol
  • BBC6
  • BCL2L8
  • BBC2
  • BCL2L8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
kinase
1
phosphatase
1
hub protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 2933   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 2933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
76.9
heel bone mineral density
2
1
2
64.6
body height
1
1
1
31
platelet count
1
1
0
4.2
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
76.9
heel bone mineral density
2
64.6
body height
1
31
platelet count
0
4.2
26.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (152)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Gene Ontology Terms (68)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (99)
1 – 10 of 99
BCL2L1
Tchem
Novelty: 0.00018414
p_int: 0.999998823
p_ni: 0.000001176
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
BCL2
Tclin
Novelty: 0.00608635
p_int: 0.999995706
p_ni: 0.000004294
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
APTX
Tbio
Novelty: 0.00812241
p_int: 0.999850866
p_ni: 0.00014911
p_wrong: 2.4e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.993
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.978
Data Source: STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.977
Data Source: STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.972
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.965
Data Source: Reactome,STRINGDB
YWHAQ
Tchem
Novelty: 0.00234496
Score: 0.964
Data Source: STRINGDB
BID
Tbio
Novelty: 0.01264688
Score: 0.964
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  52.35

PubMed score by year
PubTator Score  4053.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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