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Tbio
PTPRN2
Receptor-type tyrosine-protein phosphatase N2

Protein Summary
Description
Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinosi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389413
  • ENSP00000374064
  • ENSG00000155093
  • ENST00000389416
  • ENSP00000374067
  • ENST00000389418
  • ENSP00000374069

Symbol
  • KIAA0387
  • IAR
  • ICAAR
  • PTPRP
  • IA-2beta
  • R-PTP-N2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
trait
0.86
protein domain
0.85
virus perturbation
0.76
disease
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.96   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.96   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
p_int:  0.989771955
p_wrong:  0.010228045
Score:  0.906
Data Source:  BioPlex,STRINGDB
GHRL
Tbio
Novelty:  0.00017827
Score:  0.924
Data Source:  STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
Score:  0.775
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.731
Data Source:  STRINGDB
ENPP5
Tbio
Family:  Enzyme
Novelty:  0.11190226
Score:  0.626
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.617
Data Source:  STRINGDB
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
Score:  0.587
Data Source:  STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
Score:  0.574
Data Source:  STRINGDB
RNF32
Tdark
Novelty:  0.21111273
Score:  0.563
Data Source:  STRINGDB
MBOAT4
Tbio
Family:  Enzyme
Novelty:  0.01125747
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
3
4
68.4
mathematical ability
3
3
3
68
self reported educational attainment
3
3
3
61.3
platelet crit
1
1
1
47.7
intelligence
2
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
4
68.4
mathematical ability
3
68
self reported educational attainment
3
61.3
platelet crit
1
47.7
intelligence
2
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107418
19276
Rat
RGD:61904
29714
Dog
protein tyrosine phosphatase, receptor type N2
VGNC:45194
482825
C. elegans
175807
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type N2
C. elegans
Publication Statistics
PubMed Score 137.96
PubMed score by year
PubTator Score 68.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title