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Tbio
PTPRN2
Receptor-type tyrosine-protein phosphatase N2

Protein Summary
Description
Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinosi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389413
  • ENSP00000374064
  • ENSG00000155093
  • ENST00000389416
  • ENSP00000374067
  • ENST00000389418
  • ENSP00000374069

Symbol
  • KIAA0387
  • IAR
  • ICAAR
  • PTPRP
  • IA-2beta
  • R-PTP-N2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
trait
0.86
protein domain
0.85
virus perturbation
0.76
disease
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.81   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.81   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0