PTPRN2
Receptor-type tyrosine-protein phosphatase N2
Protein Summary
Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinosi ...more
- ENST00000389413
- ENSP00000374064
- ENSG00000155093
- ENST00000389416
- ENSP00000374067
- ENST00000389418
- ENSP00000374069
- KIAA0387
- IAR
- ICAAR
- PTPRP
- IA-2beta
- R-PTP-N2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.95 | ||
trait | 0.86 | ||
protein domain | 0.85 | ||
virus perturbation | 0.76 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.96 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 353 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.96 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 353 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (50)
PTPRN
Family: Enzyme
Novelty: 0.00076479
p_int: 0.989771955
p_wrong: 0.010228045
Score: 0.906
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (1)
Components (10)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cognitive function measurement | 3 | 3 | 4 | 68.4 | |||||
mathematical ability | 3 | 3 | 3 | 68 | |||||
self reported educational attainment | 3 | 3 | 3 | 61.3 | |||||
platelet crit | 1 | 1 | 1 | 47.7 | |||||
intelligence | 2 | 2 | 2 | 37.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cognitive function measurement | 4 | 68.4 | |||||
mathematical ability | 3 | 68 | |||||
self reported educational attainment | 3 | 61.3 | |||||
platelet crit | 1 | 47.7 | |||||
intelligence | 2 | 37.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:107418 | 19276 | ||||||
Rat | RGD:61904 | 29714 | ||||||
Dog | protein tyrosine phosphatase, receptor type N2 | VGNC:45194 | 482825 | |||||
C. elegans | 175807 | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | protein tyrosine phosphatase, receptor type N2 | |||||
C. elegans | ||||||
Publication Statistics
PubMed Score 137.96
PubMed score by year
PubTator Score 68.00
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
|---|