Tbio SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

Protein Summary

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036). The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92925
• A5PLL5
• A6NNQ7
• B4DV56
• B4E1R6
• Q7L2I6
• Q9UHZ1

Gene Name

• SMARCD2

Ensembl ID

• ENST00000323347
• ENSP00000318451
• ENSG00000108604
• ENST00000448276
• ENSP00000392617

Symbol

• BAF60B
• SGD2
• Rsc6p
• BAF60B
• CRACD2
• PRO2451

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
co-expressed gene	0.94
molecular function	0.94
transcription factor binding site profile	0.94
disease perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Swi/snf-related Matrix-associated Actin-dependent Regulator Of Chromatin Subfamily D Member 2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Swi/snf-related Matrix-associated Actin-dependent Regulator Of Chromatin Subfamily D Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.22   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.22   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0