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Tchem
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1

Protein Summary
Description
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396857
  • ENSP00000380066
  • ENSG00000104814
  • ENST00000591517
  • ENSP00000465039
  • ENST00000634395
  • ENSP00000489001
  • ENSG00000282928
  • ENST00000634494
  • ENSP00000489158

Symbol
  • HPK1
  • HPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
molecular function
0.96
drug perturbation
0.87
gene perturbation
0.87
kinase
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 531   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 531   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 74
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2