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Tchem
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1

Protein Summary
Description
Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396857
  • ENSP00000380066
  • ENSG00000104814
  • ENST00000591517
  • ENSP00000465039
  • ENST00000634395
  • ENSP00000489001
  • ENSG00000282928
  • ENST00000634494
  • ENSP00000489158

Symbol
  • HPK1
  • HPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
molecular function
0.96
drug perturbation
0.87
gene perturbation
0.87
kinase
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.43   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 531   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.43   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 531   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
DBNL
Tbio
Novelty:  0.03390948
Score:  0.996
Data Source:  STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
Score:  0.994
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.989
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.975
Data Source:  STRINGDB
LAT
Tbio
Novelty:  0.00738419
Score:  0.963
Data Source:  STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.953
Data Source:  STRINGDB
MAP3K11
Tchem
Family:  Kinase
Novelty:  0.01112378
Score:  0.951
Data Source:  STRINGDB
DAPP1
Tbio
Novelty:  0.05145215
Score:  0.949
Data Source:  STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.947
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.927
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
1
1
58.4
platelet count
1
1
1
40.7
IGF-1 measurement
1
1
1
29
reticulocyte measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
58.4
platelet count
1
40.7
IGF-1 measurement
1
29
reticulocyte measurement
1
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 1
VGNC:7488
748652
Mouse
MGI:1346882
26411
Rat
RGD:1305463
292763
Dog
mitogen-activated protein kinase kinase kinase kinase 1
VGNC:42981
484527
Horse
mitogen-activated protein kinase kinase kinase kinase 1
VGNC:19945
100064279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 1
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase kinase 1
Horse
mitogen-activated protein kinase kinase kinase kinase 1
Publication Statistics
PubMed Score 56.43
PubMed score by year
PubTator Score 37.12
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title