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Tbio
FGF14
Fibroblast growth factor 14

Protein Summary
Description
Probably involved in nervous system development and function. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376131
  • ENSP00000365301
  • ENSG00000102466
  • ENST00000376143
  • ENSP00000365313

Symbol
  • FHF4
  • FHF4
  • FHF-4
  • SCA27
  • FGF-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
microRNA
0.89
kinase perturbation
0.76
tissue
0.62
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.72   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.72   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
SCN8A
Tclin
Family:  IC
Novelty:  0.00203805
Score:  0.869
Data Source:  STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.795
Data Source:  STRINGDB
SPTBN2
Tbio
Novelty:  0.01183066
Score:  0.76
Data Source:  STRINGDB
TTBK2
Tbio
Family:  Kinase
Novelty:  0.03262289
Score:  0.739
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.73
Data Source:  STRINGDB
KCNC3
Tclin
Family:  IC
Novelty:  0.01226833
Score:  0.678
Data Source:  STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.667
Data Source:  STRINGDB
APOD
Tbio
Novelty:  0.0031899
Score:  0.666
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.661
Data Source:  STRINGDB
RAP2A
Tbio
Family:  Enzyme
Novelty:  0.00541101
Score:  0.656
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Nystagmus
1
1
0
4.3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Nystagmus
0
4.3
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 14
VGNC:13090
739338
Macaque
fibroblast growth factor 14
701077
Mouse
MGI:109189
14169
Rat
RGD:620165
63851
Dog
fibroblast growth factor 14
VGNC:54302
485537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 14
Macaque
fibroblast growth factor 14
Mouse
Rat
Dog
fibroblast growth factor 14
Publication Statistics
PubMed Score 76.72
PubMed score by year
PubTator Score 33.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title