FGF14
Fibroblast growth factor 14
Protein Summary
Probably involved in nervous system development and function. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000376131
- ENSP00000365301
- ENSG00000102466
- ENST00000376143
- ENSP00000365313
- FHF4
- FHF4
- FHF-4
- SCA27
- FGF-14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
microRNA | 0.89 | ||
kinase perturbation | 0.76 | ||
tissue | 0.62 | ||
PubMedID | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.72 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.72 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (84)
Nearest Tclin Targets
Pathways (24)
Reactome (3)
PathwayCommons (8)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Muscle contraction | ||||
Reactome | Phase 0 - rapid depolarisation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Muscle contraction | ||||
Phase 0 - rapid depolarisation | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Nystagmus | 1 | 1 | 0 | 4.3 | 21.5 | ||||
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1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Nystagmus | 0 | 4.3 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fibroblast growth factor 14 | VGNC:13090 | 739338 | |||||
Macaque | fibroblast growth factor 14 | 701077 | ||||||
Mouse | MGI:109189 | 14169 | ||||||
Rat | RGD:620165 | 63851 | ||||||
Dog | fibroblast growth factor 14 | VGNC:54302 | 485537 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fibroblast growth factor 14 | |||||
Macaque | fibroblast growth factor 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | fibroblast growth factor 14 | |||||
Publication Statistics
PubMed Score 76.72
PubMed score by year
PubTator Score 33.64
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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