SLC5A5
Sodium/iodide cotransporter
Protein Summary
Mediates iodide uptake in the thyroid gland. This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
- ENST00000222248
- ENSP00000222248
- ENSG00000105641
- NIS
- NIS
- TDH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.77 | ||
molecular function | 0.76 | ||
chemical | 0.71 | ||
PubMedID | 0.59 | ||
cellular component | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 736.32 (req: < 5)
Gene RIFs: 140 (req: <= 3)
Antibodies: 527 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 736.32 (req: >= 5)
Gene RIFs: 140 (req: > 3)
Antibodies: 527 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0