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Tbio
GATA6
Transcription factor GATA-6

Protein Summary
Description
Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defect ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269216
  • ENSP00000269216
  • ENSG00000141448
  • ENST00000581694
  • ENSP00000462313
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.99
molecular function
0.97
transcription factor binding site profile
0.83
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.36   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.36   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
63.7
lymphocyte percentage of leukocytes
1
1
1
17.6
neutrophil percentage of leukocytes
1
1
1
10.9
high density lipoprotein cholesterol measurement
1
1
1
10.8
FEV/FEC ratio
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
63.7
lymphocyte percentage of leukocytes
1
17.6
neutrophil percentage of leukocytes
1
10.9
high density lipoprotein cholesterol measurement
1
10.8
FEV/FEC ratio
1
9.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 6
VGNC:13261
468495
Macaque
GATA binding protein 6
699591
Mouse
MGI:107516
14465
Rat
RGD:2666
29300
Cow
GATA binding protein 6
654400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 6
Macaque
GATA binding protein 6
Mouse
Rat
Cow
GATA binding protein 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92908-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Factors involved in megakaryocyte development and platelet production
Hemostasis
Metabolism of proteins
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.821251539
p_ni:  0.000002797
p_wrong:  0.178745663
Data Source:  BioPlex
ZFPM2
Tbio
Family:  TF
Novelty:  0.01019523
Score:  0.962
Data Source:  STRINGDB
GATA5
Tbio
Family:  TF
Novelty:  0.00759873
Score:  0.955
Data Source:  STRINGDB
LMCD1
Tbio
Novelty:  0.06810419
Score:  0.947
Data Source:  Reactome,STRINGDB
ZFPM1
Tbio
Family:  TF
Novelty:  0.01061715
Score:  0.946
Data Source:  STRINGDB
HEY2
Tbio
Family:  TF
Novelty:  0.00569776
Score:  0.946
Data Source:  STRINGDB
HEY1
Tbio
Family:  TF
Novelty:  0.0042366
Score:  0.942
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.941
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.932
Data Source:  STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
Score:  0.93
Data Source:  STRINGDB
Publication Statistics
PubMed Score  417.36

PubMed score by year
PubTator Score  207.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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