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Tbio
ERCC4
DNA repair endonuclease XPF

Protein Summary
Description
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311895
  • ENSP00000310520
  • ENSG00000175595
  • ENST00000575156
  • ENSP00000459933

Symbol
  • ERCC11
  • XPF
  • XPF
  • RAD1
  • FANCQ
  • XFEPS
  • ERCC11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.86
virus perturbation
0.85
histone modification site profile
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.02   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 450   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.02   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
ERCC1
Tbio
Novelty:  0.00079472
p_int:  0.999999981
p_ni:  1.8e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
XPA
Tchem
Novelty:  0.00137698
p_int:  0.999976589
p_ni:  0.000023411
Score:  0.998
Data Source:  BioPlex,STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
p_int:  0.999819341
p_ni:  0.000180659
Score:  0.998
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.995955913
p_ni:  0.004043945
p_wrong:  1.42e-7
Score:  0.212
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.995420935
p_ni:  0.004579062
p_wrong:  3e-9
Data Source:  BioPlex
NFKBID
Tbio
Novelty:  0.04272718
p_int:  0.993531741
p_ni:  0.006468259
Score:  0.19
Data Source:  BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.989427933
p_ni:  0.01057206
p_wrong:  7e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.98650224
p_ni:  0.01345085
p_wrong:  0.000046911
Data Source:  BioPlex
C10orf55
Tdark
Novelty:  5.92242744
p_int:  0.983274791
p_ni:  0.016725209
Score:  0.54
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.856544505
p_ni:  0.142727966
p_wrong:  0.000727529
Score:  0.519
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
9.6
intelligence
1
1
0
5.8
1.5
self reported educational attainment
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
9.6
intelligence
0
5.8
1.5
self reported educational attainment
1
0.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 4, endonuclease catalytic subunit
VGNC:9004
453935
Macaque
ERCC excision repair 4, endonuclease catalytic subunit
712641
Mouse
MGI:1354163
50505
Rat
Dog
ERCC excision repair 4, endonuclease catalytic subunit
VGNC:40444
479842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 4, endonuclease catalytic subunit
Macaque
ERCC excision repair 4, endonuclease catalytic subunit
Mouse
Rat
Dog
ERCC excision repair 4, endonuclease catalytic subunit
Publication Statistics
PubMed Score 80.02
PubMed score by year
PubTator Score 256.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title