ERCC4
DNA repair endonuclease XPF
Protein Summary
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
- ENST00000311895
- ENSP00000310520
- ENSG00000175595
- ENST00000575156
- ENSP00000459933
- ERCC11
- XPF
- XPF
- RAD1
- FANCQ
- XFEPS
- ERCC11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
molecular function | 0.86 | ||
virus perturbation | 0.85 | ||
histone modification site profile | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.78 (req: < 5)
Gene RIFs: 129 (req: <= 3)
Antibodies: 450 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 87.78 (req: >= 5)
Gene RIFs: 129 (req: > 3)
Antibodies: 450 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0