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Tbio
ERCC4
DNA repair endonuclease XPF

Protein Summary
Description
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311895
  • ENSP00000310520
  • ENSG00000175595
  • ENST00000575156
  • ENSP00000459933

Symbol
  • ERCC11
  • XPF
  • XPF
  • RAD1
  • FANCQ
  • XFEPS
  • ERCC11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.86
virus perturbation
0.85
histone modification site profile
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.48   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 450   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.48   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Fanconi Anemia Pathway
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (239)
1 – 10 of 239
ERCC1
Tbio
Novelty: 0.00089943
p_int: 0.999999981
p_ni: 1.8e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
XPA
Tbio
Novelty: 0.00128557
p_int: 0.999976589
p_ni: 0.000023411
Score: 0.998
Data Source: BioPlex,STRINGDB
MUS81
Tbio
Family: Enzyme
Novelty: 0.0066722
p_int: 0.999819341
p_ni: 0.000180659
Score: 0.998
Data Source: BioPlex,STRINGDB
PIAS4
Tbio
Family: TF
Novelty: 0.01658213
p_int: 0.995955913
p_ni: 0.004043945
p_wrong: 1.42e-7
Score: 0.212
Data Source: BioPlex,STRINGDB
GYPB
Tbio
Novelty: 0.00257625
p_int: 0.995420935
p_ni: 0.004579062
p_wrong: 3e-9
Data Source: BioPlex
NFKBID
Tbio
Novelty: 0.05906388
p_int: 0.993531741
p_ni: 0.006468259
Score: 0.19
Data Source: BioPlex,STRINGDB
ZFC3H1
Tdark
Novelty: 0.234375
p_int: 0.989427933
p_ni: 0.01057206
p_wrong: 7e-9
Score: 0.155
Data Source: BioPlex,STRINGDB
KCTD3
Tdark
Novelty: 0.4635514
p_int: 0.98650224
p_ni: 0.01345085
p_wrong: 0.000046911
Data Source: BioPlex
C10orf55
Tdark
Novelty: 3
p_int: 0.983274791
p_ni: 0.016725209
Score: 0.54
Data Source: BioPlex,STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00071387
p_int: 0.856544505
p_ni: 0.142727966
p_wrong: 0.000727529
Score: 0.519
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  61.48

PubMed score by year
PubTator Score  256.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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