Tbio ARHGEF1 Rho guanine nucleotide exchange factor 1

Protein Summary

Description

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92888
• O00513
• Q6NX52
• Q8N4J4
• Q96BF4
• Q96F17
• Q9BSB1

Gene Name

• ARHGEF1

Ensembl ID

• ENST00000337665
• ENSP00000337261
• ENSG00000076928
• ENST00000347545
• ENSP00000344429
• ENST00000354532
• ENSP00000346532
• ENST00000378152
• ENSP00000367394

Symbol

• LSC
• GEF1
• LBCL2
• SUB1.5
• P115-RHOGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
drug perturbation	0.87
protein domain	0.85
disease perturbation	0.79
hub protein	0.75

Protein Classes

DTO Classes

Rho Guanine Nucleotide Exchange Factor 10 / Rho Guanine Nucleotide Exchange Factor 10-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.44   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 247   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.44   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0