You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ABCC2
Canalicular multispecific organic anion transporter 1

Protein Summary
Description
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370449
  • ENSP00000359478
  • ENSG00000023839
  • ENST00000647814
  • ENSP00000497274

Symbol
  • CMOAT
  • CMOAT1
  • CMRP
  • MRP2
  • DJS
  • MRP2
  • cMRP
  • ABC30
  • CMOAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
molecular function
1
biological term
0.97
protein domain
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.13   (req: < 5)
Gene RIFs: 218   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.13   (req: >= 5)
Gene RIFs: 218   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
PAK-104P
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily C member 2
574169
Mouse
MGI:1352447
12780
Rat
RGD:2366
25303
Dog
ATP binding cassette subfamily C member 2
VGNC:37440
403632
Horse
ATP binding cassette subfamily C member 2
VGNC:14917
100060654
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily C member 2
Mouse
Rat
Dog
ATP binding cassette subfamily C member 2
Horse
ATP binding cassette subfamily C member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92887-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCC2 causes Dubin-Johnson syndrome
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective ABCC2 causes Dubin-Johnson syndrome
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (148)
1 – 10 of 148
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.936
Data Source: STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00029779
Score: 0.906
Data Source: STRINGDB
SLCO1B1
Tchem
Family: Transporter
Novelty: 0.00126613
Score: 0.825
Data Source: STRINGDB
SLCO1B3
Tchem
Family: Transporter
Novelty: 0.0031518
Score: 0.815
Data Source: STRINGDB
NR1H4
Tclin
Family: NR
Novelty: 0.00067092
Score: 0.79
Data Source: STRINGDB
SLC30A5
Tbio
Family: Transporter
Novelty: 0.02432633
Score: 0.786
Data Source: STRINGDB
SLC10A1
Tchem
Family: Transporter
Novelty: 0.00142951
Score: 0.77
Data Source: STRINGDB
UGT1A6
Tbio
Family: Enzyme
Novelty: 0.00146917
Score: 0.768
Data Source: STRINGDB
UGT1A1
Tchem
Family: Enzyme
Novelty: 0.00135044
Score: 0.762
Data Source: STRINGDB
UGT1A8
Tbio
Family: Enzyme
Novelty: 0.00135129
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  964.13

PubMed score by year
PubTator Score  832.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer