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Tbio
NEUROG1
Neurogenin-1

Protein Summary
Description
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314744
  • ENSP00000317580
  • ENSG00000181965

Symbol
  • BHLHA6
  • NEUROD3
  • NGN
  • NGN1
  • AKA
  • ngn1
  • Math4C
  • bHLHa6
  • NEUROD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
PubMedID
0.68
molecular function
0.63
transcription factor binding site profile
0.58
cell type or tissue
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.16   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 535   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.16   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 535   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurogenin 1
VGNC:13552
746658
Macaque
neurogenin 1
711992
Mouse
MGI:107754
18014
Rat
RGD:3167
29410
Dog
neurogenin 1
VGNC:43756
481516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurogenin 1
Macaque
neurogenin 1
Mouse
Rat
Dog
neurogenin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92886-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (35)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (113)
1 – 10 of 113
CACNA1G
Tclin
Family: IC
Novelty: 0.00380386
Score: 0.798
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.797
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.785
Data Source: STRINGDB
ELAVL3
Tbio
Novelty: 0.00143503
Score: 0.782
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.779
Data Source: STRINGDB
RUNX3
Tbio
Family: TF
Novelty: 0.00144472
Score: 0.732
Data Source: STRINGDB
CRABP1
Tbio
Novelty: 0.00284292
Score: 0.731
Data Source: STRINGDB
SOX5
Tbio
Family: TF
Novelty: 0.00623121
Score: 0.718
Data Source: STRINGDB
BCS1L
Tbio
Family: Enzyme
Novelty: 0.01764582
Score: 0.716
Data Source: STRINGDB
FEZF2
Tbio
Family: TF
Novelty: 0.01641588
Score: 0.714
Data Source: STRINGDB
Publication Statistics
PubMed Score  191.16

PubMed score by year
PubTator Score  87.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer