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Tbio
CELF1
CUGBP Elav-like family member 1

Protein Summary
Description
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310513
  • ENSP00000308386
  • ENSG00000149187
  • ENST00000358597
  • ENSP00000351409
  • ENST00000361904
  • ENSP00000354639
  • ENST00000395290
  • ENSP00000378705
  • ENST00000395292
  • ENSP00000378706
  • ENST00000532048
  • ENSP00000435926

Symbol
  • BRUNOL2
  • CUGBP
  • CUGBP1
  • NAB50
  • CUGBP
  • NAB50
  • NAPOR
  • CUG-BP
  • CUGBP1
  • hNab50
  • BRUNOL2
  • EDEN-BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
disease perturbation
0.79
interacting protein
0.79
transcription factor
0.79
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.18   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.18   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (141)
1 – 10 of 141
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.908358935
p_ni:  0.090725423
p_wrong:  0.000915643
Data Source:  BioPlex
MBNL1
Tbio
Novelty:  0.00441241
Score:  0.944
Data Source:  STRINGDB
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.935
Data Source:  STRINGDB
RALY
Tbio
Novelty:  0.03883322
Score:  0.863
Data Source:  STRINGDB
DMPK
Tchem
Family:  Kinase
Novelty:  0.00242339
Score:  0.844
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.836
Data Source:  STRINGDB
CEBPD
Tbio
Family:  TF
Novelty:  0.00121121
Score:  0.83
Data Source:  STRINGDB
MBNL2
Tbio
Novelty:  0.02398556
Score:  0.818
Data Source:  STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.807
Data Source:  STRINGDB
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
Score:  0.794
Data Source:  STRINGDB
GWAS Traits (71)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4
26
97.2
high density lipoprotein cholesterol measurement
1
4
4
96.3
intraocular pressure measurement
3
3
3
90.7
body height
2
2
2
90.1
apolipoprotein A 1 measurement
1
3
3
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
26
97.2
high density lipoprotein cholesterol measurement
4
96.3
intraocular pressure measurement
3
90.7
body height
2
90.1
apolipoprotein A 1 measurement
3
90
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CUGBP Elav-like family member 1
713167
Mouse
MGI:1342295
13046
Rat
RGD:1307721
362160
Dog
CUGBP Elav-like family member 1
VGNC:39093
475979
Horse
CUGBP Elav-like family member 1
VGNC:16386
100051608
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CUGBP Elav-like family member 1
Mouse
Rat
Dog
CUGBP Elav-like family member 1
Horse
CUGBP Elav-like family member 1
Publication Statistics
PubMed Score 192.18
PubMed score by year
PubTator Score 105.17
PubTator score by year