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Tbio
RAD50
DNA repair protein RAD50

Protein Summary
Description
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378823
  • ENSP00000368100
  • ENSG00000113522

Symbol
  • NBSLD
  • RAD502
  • hRad50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein complex
1
hub protein
0.85
biological process
0.79
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.11   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 425   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.11   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 425   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (229)
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.999991203
p_ni:  0.000008797
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999902666
p_ni:  0.000097334
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99954836
p_ni:  0.00045164
Data Source:  BioPlex
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.998297987
p_ni:  0.001702013
Data Source:  BioPlex
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.997384297
p_ni:  0.002615703
Data Source:  BioPlex
CELA2B
Tdark
Family:  Enzyme
Novelty:  0.43122129
p_int:  0.989716605
p_ni:  0.010283395
Score:  0.169
Data Source:  BioPlex,STRINGDB
LRRC39
Tdark
Novelty:  0.70657884
p_int:  0.989404537
p_ni:  0.010595463
Score:  0.196
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.983989086
p_ni:  0.016010914
Data Source:  BioPlex
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.968021715
p_ni:  0.031978286
Score:  0.169
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.961842578
p_ni:  0.038157422
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
11
11
7.1
99.6
eosinophil percentage of leukocytes
2
6
8
99.1
10
16
1
1.1
97.7
childhood onset asthma
3
4
0
1.2
96.9
sum of eosinophil and basophil counts
1
2
2
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
11
7.1
99.6
eosinophil percentage of leukocytes
8
99.1
1
1.1
97.7
childhood onset asthma
0
1.2
96.9
sum of eosinophil and basophil counts
2
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAD50 double strand break repair protein
710718
Mouse
MGI:109292
19360
Rat
RGD:621542
64012
Dog
RAD50 double strand break repair protein
VGNC:51759
474674
Horse
RAD50 double strand break repair protein
100063198
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAD50 double strand break repair protein
Mouse
Rat
Dog
RAD50 double strand break repair protein
Horse
RAD50 double strand break repair protein
Publication Statistics
PubMed Score 37.11
PubMed score by year
PubTator Score 267.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title