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Tchem
KLK6
Kallikrein-6

Protein Summary
Description
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310157
  • ENSP00000309148
  • ENSG00000167755
  • ENST00000376851
  • ENSP00000366047
  • ENST00000391808
  • ENSP00000375684
  • ENST00000594641
  • ENSP00000470482
  • ENST00000597379
  • ENSP00000469630
  • ENST00000599881
  • ENSP00000471948

Symbol
  • PRSS18
  • PRSS9
  • hK6
  • Bssp
  • Klk7
  • SP59
  • PRSS9
  • PRSS18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cellular component
0.7
PubMedID
0.7
biological term
0.64
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.32   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.32   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kallikrein‐6 measurement
1
1
1
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kallikrein‐6 measurement
1
80.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kallikrein related peptidase 6
719776
Mouse
MGI:1343166
19144
Rat
RGD:3419
29245
Dog
kallikrein related peptidase 6 [Source:HGNC Symbol;Acc:HGNC:6367]
Horse
kallikrein related peptidase 6
VGNC:19488
100146510
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kallikrein related peptidase 6
Mouse
Rat
Dog
kallikrein related peptidase 6 [Source:HGNC Symbol;Acc:HGNC:6367]
Horse
kallikrein related peptidase 6
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92876-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.999974435
p_ni: 0.000025565
Score: 0.19
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.957410393
p_ni: 0.031208211
p_wrong: 0.011381396
Score: 0.185
Data Source: BioPlex,STRINGDB
FBXO42
Tbio
Novelty: 0.17658866
p_int: 0.941217559
p_ni: 0.05866974
p_wrong: 0.000112701
Score: 0.187
Data Source: BioPlex,STRINGDB
CDYL
Tchem
Family: Epigenetic
Novelty: 0.03367841
p_int: 0.878389398
p_ni: 0.120745565
p_wrong: 0.000865037
Score: 0.175
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.823741851
p_ni: 0.176258149
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.800426201
p_ni: 0.199573799
Data Source: BioPlex
EMC7
Tdark
Novelty: 0.28771768
p_int: 0.771061866
p_ni: 0.228846168
p_wrong: 0.000091965
Score: 0.163
Data Source: BioPlex,STRINGDB
SNCA
Tchem
Novelty: 0.00012042
Score: 0.959
Data Source: STRINGDB
A2ML1
Tbio
Novelty: 0.05923067
Score: 0.719
Data Source: STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00451563
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  232.32

PubMed score by year
PubTator Score  150.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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