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Tchem
KLK6
Kallikrein-6

Protein Classes
Protein Summary
Description
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310157
  • ENSP00000309148
  • ENSG00000167755
  • ENST00000376851
  • ENSP00000366047
  • ENST00000391808
  • ENSP00000375684
  • ENST00000594641
  • ENSP00000470482
  • ENST00000597379
  • ENSP00000469630
  • ENST00000599881
  • ENSP00000471948

Symbol
  • PRSS18
  • PRSS9
  • hK6
  • Bssp
  • Klk7
  • SP59
  • PRSS9
  • PRSS18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cellular component
0.7
PubMedID
0.7
biological term
0.64
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.44   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.44   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
CPSF4
Tbio
Novelty: 0.00211961
p_int: 0.999974435
p_ni: 0.000025565
Score: 0.19
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.01450464
p_int: 0.957410393
p_ni: 0.031208211
p_wrong: 0.011381396
Score: 0.185
Data Source: BioPlex,STRINGDB
FBXO42
Tbio
Novelty: 0.01292089
p_int: 0.941217559
p_ni: 0.05866974
p_wrong: 0.000112701
Score: 0.187
Data Source: BioPlex,STRINGDB
CDYL
Tchem
Family: Epigenetic
Novelty: 0.04830646
p_int: 0.878389398
p_ni: 0.120745565
p_wrong: 0.000865037
Score: 0.175
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.02626744
p_int: 0.823741851
p_ni: 0.176258149
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00281462
p_int: 0.800426201
p_ni: 0.199573799
Data Source: BioPlex
EMC7
Tdark
Novelty: 1.28514589
p_int: 0.771061866
p_ni: 0.228846168
p_wrong: 0.000091965
Score: 0.163
Data Source: BioPlex,STRINGDB
SNCA
Tchem
Novelty: 0.00021357
Score: 0.959
Data Source: STRINGDB
A2ML1
Tbio
Novelty: 0.10064763
Score: 0.719
Data Source: STRINGDB
SPINK5
Tbio
Family: Enzyme
Novelty: 0.00033689
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  181.44

PubMed score by year
PubTator Score  150.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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