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Tbio
PMM1
Phosphomannomutase 1

Protein Summary
Description
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216259
  • ENSP00000216259
  • ENSG00000100417

Symbol
  • PMMH22
  • PMM 1
  • Sec53
  • PMMH-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.76
tissue sample
0.67
disease perturbation
0.62
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.99   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.99   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
67.7
self reported educational attainment
2
2
2
63.6
intelligence
2
2
0
6.6
59.9
birth weight
1
1
1
57.8
monocyte count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
67.7
self reported educational attainment
2
63.6
intelligence
0
6.6
59.9
birth weight
1
57.8
monocyte count
1
49.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphomannomutase 1
VGNC:5299
458867
Macaque
phosphomannomutase 1
707866
Mouse
MGI:1353418
29858
Rat
RGD:1310897
300089
Dog
phosphomannomutase 1
VGNC:44733
474486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphomannomutase 1
Macaque
phosphomannomutase 1
Mouse
Rat
Dog
phosphomannomutase 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q92871-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of GDP-mannose
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of GDP-mannose
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
PMM2
Tchem
Family:  Enzyme
Novelty:  0.01177513
p_int:  1
Score:  0.902
Data Source:  BioPlex,STRINGDB
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999989707
p_ni:  0.000006937
p_wrong:  0.000003356
Score:  0.227
Data Source:  BioPlex,STRINGDB
QRICH1
Tdark
Novelty:  0.27714699
p_int:  0.998143824
p_ni:  0.001856175
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.969601825
p_ni:  0.030398141
p_wrong:  3.4e-8
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.969197598
p_ni:  0.030802387
p_wrong:  1.5e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.958254601
p_ni:  0.041744166
p_wrong:  0.000001233
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.793933701
p_ni:  0.206055354
p_wrong:  0.000010945
Score:  0.159
Data Source:  BioPlex,STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.974
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.967
Data Source:  STRINGDB
GMPPA
Tbio
Family:  Enzyme
Novelty:  0.14050797
Score:  0.942
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.99

PubMed score by year
PubTator Score  14.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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