Protein Summary
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
- ENST00000339861
- ENSP00000344923
- ENSG00000187764
- ENST00000356444
- ENSP00000348822
- ENST00000420987
- ENSP00000391733
- ENST00000422704
- ENSP00000388768
- ENST00000438547
- ENSP00000405102
- ENST00000450295
- ENSP00000416523
- ENST00000455551
- ENSP00000411981
- C9orf164
- CD100
- SEMAJ
- CD100
- COLL4
- SEMAJ
- coll-4
- C9orf164
- M-sema-G
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
biological process | 0.98 | ||
disease perturbation | 0.83 | ||
microRNA | 0.8 | ||
cell line | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.26 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 795 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.26 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 795 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (106)
SCGB2A2
Novelty: 0.01594053
p_int: 0.99996221
p_ni: 0.000009487
p_wrong: 0.000028302
Score: 0.198
Data Source: BioPlex,STRINGDB
SCGB1D1
Novelty: 0.04199997
p_int: 0.999743484
p_ni: 0.000217704
p_wrong: 0.000038812
Data Source: BioPlex
VCAM1
Novelty: 0.00022504
p_int: 0.999612167
p_ni: 0.000387833
Score: 0.261
Data Source: BioPlex,STRINGDB
LCN6
Novelty: 0.11406686
p_int: 0.999506993
p_ni: 0.00036848
p_wrong: 0.000124527
Data Source: BioPlex
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.996746675
p_ni: 0.001443269
p_wrong: 0.001810055
Score: 0.278
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (9)
Reactome (7)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | Sema4D in semaphorin signaling | ||||
Reactome | Sema4D induced cell migration and growth-cone collapse | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
Sema4D in semaphorin signaling | ||||
Sema4D induced cell migration and growth-cone collapse | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (7)
Components (3)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 5 | 6 | 77 | |||||
reticulocyte measurement | 2 | 2 | 2 | 76.7 | |||||
body mass index | 3 | 3 | 2 | 2.9 | 67.1 | ||||
triglyceride measurement | 2 | 2 | 2 | 63.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 56.8 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 77 | |||||
reticulocyte measurement | 2 | 76.7 | |||||
body mass index | 2 | 2.9 | 67.1 | ||||
triglyceride measurement | 2 | 63.6 | |||||
mean corpuscular volume | 1 | 56.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 4D | VGNC:13960 | 464584 | |||||
Macaque | semaphorin 4D | 697697 | ||||||
Mouse | MGI:109244 | 20354 | ||||||
Rat | RGD:1310554 | 306790 | ||||||
Dog | semaphorin 4D | VGNC:53974 | 476350 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | semaphorin 4D | |||||
Macaque | semaphorin 4D | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 4D | |||||
Publication Statistics
PubMed Score 280.26
PubMed score by year
PubTator Score 187.48
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (68)
Items per page:
0 of 0
PMID | Year | Title |
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