Tbio SEMA4D Semaphorin-4D

Protein Summary

Description

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

Uniprot Accession IDs

• Q92854
• B2RPM6
• Q7Z5S4
• Q8N8B0

Gene Name

• SEMA4D

Ensembl ID

• ENST00000339861
• ENSP00000344923
• ENSG00000187764
• ENST00000356444
• ENSP00000348822
• ENST00000420987
• ENSP00000391733
• ENST00000422704
• ENSP00000388768
• ENST00000438547
• ENSP00000405102
• ENST00000450295
• ENSP00000416523
• ENST00000455551
• ENSP00000411981

Symbol

• C9orf164
• CD100
• SEMAJ
• CD100
• COLL4
• SEMAJ
• coll-4
• C9orf164
• M-sema-G

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
biological process	0.98
disease perturbation	0.83
microRNA	0.8
cell line	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4d

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 329.24   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 795   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 329.24   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 795   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0