Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associ ...more
- ENST00000272879
- ENSP00000272879
- ENSG00000003400
- ENST00000286186
- ENSP00000286186
- ENST00000313728
- ENSP00000314599
- ENST00000346817
- ENSP00000237865
- ENST00000360132
- ENSP00000353250
- ENST00000374650
- ENSP00000363781
- ENST00000448480
- ENSP00000396835
- MCH4
- MCH4
- ALPS2
- FLICE2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
co-expressed gene | 0.85 | ||
PubMedID | 0.84 | ||
cell type or tissue | 0.69 | ||
tissue sample | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.66 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 554 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.66 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 554 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (107)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (127)
Reactome (14)
KEGG (5)
PathwayCommons (8)
WikiPathways (100)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | FasL/ CD95L signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Death Receptor Signalling | ||||
FasL/ CD95L signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 1 | 1.1 | 97.2 | |||||
lymphocyte count | 3 | 3 | 3 | 95.8 | |||||
platelet crit | 2 | 2 | 2 | 89.1 | |||||
keratinocyte carcinoma | 1 | 1 | 0 | 1.1 | 83.8 | ||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 83.6 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 97.2 | |||||
lymphocyte count | 3 | 95.8 | |||||
platelet crit | 2 | 89.1 | |||||
keratinocyte carcinoma | 0 | 1.1 | 83.8 | ||||
lymphocyte percentage of leukocytes | 2 | 83.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | caspase 10 | VGNC:10628 | 459873 | |||||
Dog | caspase 10 | 488472 | ||||||
Horse | caspase 10 | VGNC:49316 | 100068201 | |||||
Pig | caspase 10 | 100154896 | ||||||
Opossum | caspase-10 | 100016987 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | caspase 10 | |||||
Dog | caspase 10 | |||||
Horse | caspase 10 | |||||
Pig | caspase 10 | |||||
Opossum | caspase-10 | |||||
Publication Statistics
PubMed Score 114.66
PubMed score by year
PubTator Score 206.31
PubTator score by year
Related Publications
Text Mined References (128)
GeneRif Annotations (57)
Items per page:
0 of 0
PMID | Year | Title |
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