Tchem CASP10 Caspase-10

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-10

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-10

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-10

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q92851
• Q68HC0
• Q6KF62
• Q6KF63
• Q8IUP5
• Q8WYQ8
• Q99845
• Q9Y2U6
• Q9Y2U7
• CASP-10

Gene Name

• CASP10

Ensembl ID

• ENST00000272879
• ENSP00000272879
• ENSG00000003400
• ENST00000286186
• ENSP00000286186
• ENST00000313728
• ENSP00000314599
• ENST00000346817
• ENSP00000237865
• ENST00000360132
• ENSP00000353250
• ENST00000374650
• ENSP00000363781
• ENST00000448480
• ENSP00000396835

Symbol

• MCH4
• MCH4
• ALPS2
• FLICE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
co-expressed gene	0.85
PubMedID	0.84
cell type or tissue	0.69
tissue sample	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.68   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 554   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.68   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (5)

Explore Active Ligands

1 – 5 of 5

CHEMBL366927

CASP10Tchem Enzyme

IC50: 7.75

CHEMBL179503

CASP10Tchem Enzyme

IC50: 7.53

CHEMBL2324339

CASP10Tchem Enzyme

IC50: 6.89

CHEMBL2324341

CASP10Tchem Enzyme

IC50: 6.23

CHEMBL2323967

CASP10Tchem Enzyme

IC50: 6.38

Pathways (127)

Reactome (14)

KEGG (5)

PathwayCommons (8)

WikiPathways (100)

DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Items per page:

5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887
Reactome	FasL/ CD95L signaling	5 targets	R-HSA-75157
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Death Receptor Signalling	141 targets	R-HSA-73887
FasL/ CD95L signaling	5 targets	R-HSA-75157
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (16)

Functions (5)

Components (4)

Processes (7)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
death effector domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Inferred from Mutant Phenotype (IMP)	UniProtKB
cysteine-type endopeptidase activity involved in apoptotic process	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

TNFRSF10B

Tbio

Novelty: 0.0006573

Score: 0.999

Data Source: Reactome,STRINGDB

TNFRSF10A

Tchem

Novelty: 0.0003938

Score: 0.999

Data Source: Reactome,STRINGDB

CASP8

Tchem

Family: Enzyme

Novelty: 0.00026844

Score: 0.999

Data Source: Reactome,STRINGDB

FAS

Tbio

Novelty: 0.00049744

Score: 0.999

Data Source: Reactome,STRINGDB

FADD

Tbio

Novelty: 0.00183502

Score: 0.992

Data Source: Reactome,STRINGDB

CFLAR

Tbio

Novelty: 0.00120225

Score: 0.99

Data Source: STRINGDB

CASP3

Tchem

Family: Enzyme

Novelty: 0.00004276

Score: 0.988

Data Source: STRINGDB

CASP7

Tchem

Family: Enzyme

Novelty: 0.00186906

Score: 0.988

Data Source: STRINGDB

FASLG

Tbio

Novelty: 0.00036473

Score: 0.981

Data Source: Reactome,STRINGDB

RIPK1

Tchem

Family: Kinase

Novelty: 0.00302762

Score: 0.974

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  91.68

PubMed score by year

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PubTator Score  206.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDL

1-70

LSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD

70-140

SLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQG

140-210

EEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNR

210-280

NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDC

280-350

FVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE

350-420

QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTV

420-490

WGAKQISATSLPTAISAQTPRPPMRRWSSVS

490-521

MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS

Find similar targets by:

Uniprot Keyword

Alternative splicing
Apoptosis
Complete proteome
Direct protein sequencing
Disease mutation
Hydrolase
Polymorphism
Protease
Reference proteome
Repeat