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Tchem
CASP10
Caspase-10

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272879
  • ENSP00000272879
  • ENSG00000003400
  • ENST00000286186
  • ENSP00000286186
  • ENST00000313728
  • ENSP00000314599
  • ENST00000346817
  • ENSP00000237865
  • ENST00000360132
  • ENSP00000353250
  • ENST00000374650
  • ENSP00000363781
  • ENST00000448480
  • ENSP00000396835

Symbol
  • MCH4
  • MCH4
  • ALPS2
  • FLICE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
co-expressed gene
0.85
PubMedID
0.84
cell type or tissue
0.69
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.66   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.66   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (107)
TNFRSF10B
Tbio
Novelty:  0.00054433
Score:  0.999
Data Source:  Reactome,STRINGDB
TNFRSF10A
Tchem
Novelty:  0.0003383
Score:  0.999
Data Source:  Reactome,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  Reactome,STRINGDB
FAS
Tbio
Novelty:  0.00043286
Score:  0.999
Data Source:  Reactome,STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.992
Data Source:  Reactome,STRINGDB
CFLAR
Tbio
Novelty:  0.00108805
Score:  0.99
Data Source:  STRINGDB
CASP7
Tchem
Family:  Enzyme
Novelty:  0.00126224
Score:  0.988
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.988
Data Source:  STRINGDB
FASLG
Tbio
Novelty:  0.0003303
Score:  0.981
Data Source:  Reactome,STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.974
Data Source:  Reactome,STRINGDB
Pathways (127)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Death Receptor Signalling
Reactome
FasL/ CD95L signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Death Receptor Signalling
FasL/ CD95L signaling
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
1
1.1
97.2
lymphocyte count
3
3
3
95.8
platelet crit
2
2
2
89.1
keratinocyte carcinoma
1
1
0
1.1
83.8
lymphocyte percentage of leukocytes
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97.2
lymphocyte count
3
95.8
platelet crit
2
89.1
keratinocyte carcinoma
0
1.1
83.8
lymphocyte percentage of leukocytes
2
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 10
VGNC:10628
459873
Dog
caspase 10
488472
Horse
caspase 10
VGNC:49316
100068201
Pig
caspase 10
100154896
Opossum
caspase-10
100016987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 10
Dog
caspase 10
Horse
caspase 10
Pig
caspase 10
Opossum
caspase-10
Publication Statistics
PubMed Score 114.66
PubMed score by year
PubTator Score 206.31
PubTator score by year
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Related Publications
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PMID
Year
Title