Tchem CASP10 Caspase-10

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q92851
• Q68HC0
• Q6KF62
• Q6KF63
• Q8IUP5
• Q8WYQ8
• Q99845
• Q9Y2U6
• Q9Y2U7
• CASP-10

Gene Name

• CASP10

Ensembl ID

• ENST00000272879
• ENSP00000272879
• ENSG00000003400
• ENST00000286186
• ENSP00000286186
• ENST00000313728
• ENSP00000314599
• ENST00000346817
• ENSP00000237865
• ENST00000360132
• ENSP00000353250
• ENST00000374650
• ENSP00000363781
• ENST00000448480
• ENSP00000396835

Symbol

• MCH4
• MCH4
• ALPS2
• FLICE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
co-expressed gene	0.85
PubMedID	0.84
cell type or tissue	0.69
tissue sample	0.68

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-10

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-10

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.7   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 554   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.7   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0