Tchem CASP10 Caspase-10

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-10

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-10

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-10

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q92851
• Q68HC0
• Q6KF62
• Q6KF63
• Q8IUP5
• Q8WYQ8
• Q99845
• Q9Y2U6
• Q9Y2U7
• CASP-10

Gene Name

• CASP10

Ensembl ID

• ENST00000272879
• ENSP00000272879
• ENSG00000003400
• ENST00000286186
• ENSP00000286186
• ENST00000313728
• ENSP00000314599
• ENST00000346817
• ENSP00000237865
• ENST00000360132
• ENSP00000353250
• ENST00000374650
• ENSP00000363781
• ENST00000448480
• ENSP00000396835

Symbol

• MCH4
• MCH4
• ALPS2
• FLICE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
co-expressed gene	0.85
PubMedID	0.84
cell type or tissue	0.69
tissue sample	0.68

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.72   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 554   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.72   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (5)

Explore Active Ligands

1 – 5 of 5

CHEMBL366927

CASP10Tchem Enzyme

IC50 : 7.75

CHEMBL179503

CASP10Tchem Enzyme

IC50 : 7.53

CHEMBL2324339

CASP10Tchem Enzyme

IC50 : 6.89

CHEMBL2324341

CASP10Tchem Enzyme

IC50 : 6.23

CHEMBL2323967

CASP10Tchem Enzyme

IC50 : 6.38

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		54.8
chronic lymphocytic leukemia	EFO_0000095	1	1	0	1.2	41.4
rheumatoid arthritis	EFO_0000685	1	1	0	1.2	41.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		54.8
chronic lymphocytic leukemia	EFO_0000095	0	1.2	41.4
rheumatoid arthritis	EFO_0000685	0	1.2	41.4

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Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	caspase 10	VGNC:10628	459873
Dog	caspase 10		488472
Horse	caspase 10	VGNC:49316	100068201
Pig	caspase 10		100154896
Opossum	caspase-10		100016987

Species	Name	OMA	EggNOG	Inparanoid
Chimp	caspase 10
Dog	caspase 10
Horse	caspase 10
Pig	caspase 10
Opossum	caspase-10

Pathways (127)

Reactome (14)

KEGG (5)

PathwayCommons (8)

WikiPathways (100)

DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887
Reactome	FasL/ CD95L signaling	5 targets	R-HSA-75157
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Death Receptor Signalling	141 targets	R-HSA-73887
FasL/ CD95L signaling	5 targets	R-HSA-75157
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (16)

Functions (5)

Components (4)

Processes (7)

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1 – 5 of 5

GO Term	Evidence	Assigned by
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
death effector domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Inferred from Mutant Phenotype (IMP)	UniProtKB
cysteine-type endopeptidase activity involved in apoptotic process	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

TNFRSF10B

Tbio

Novelty: 0.00054433

Score: 0.999

Data Source: Reactome,STRINGDB

TNFRSF10A

Tchem

Novelty: 0.0003383

Score: 0.999

Data Source: Reactome,STRINGDB

CASP8

Tchem

Family: Enzyme

Novelty: 0.00024321

Score: 0.999

Data Source: Reactome,STRINGDB

FAS

Tbio

Novelty: 0.00043286

Score: 0.999

Data Source: Reactome,STRINGDB

FADD

Tbio

Novelty: 0.00137968

Score: 0.992

Data Source: Reactome,STRINGDB

CFLAR

Tbio

Novelty: 0.00108805

Score: 0.99

Data Source: STRINGDB

CASP3

Tchem

Family: Enzyme

Novelty: 0.00003555

Score: 0.988

Data Source: STRINGDB

CASP7

Tchem

Family: Enzyme

Novelty: 0.00126224

Score: 0.988

Data Source: STRINGDB

FASLG

Tbio

Novelty: 0.0003303

Score: 0.981

Data Source: Reactome,STRINGDB

RIPK1

Tchem

Family: Kinase

Novelty: 0.00230565

Score: 0.974

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  113.72

PubMed score by year

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PubTator Score  206.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Apoptosis
Complete proteome
Direct protein sequencing
Disease mutation
Hydrolase
Polymorphism
Protease
Reference proteome
Repeat

GWAS Trait Find Similar Targets

chronic lymphocytic leukemia
mean corpuscular hemoglobin concentration
rheumatoid arthritis