Protein Classes
Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associ ...more
- ENST00000272879
- ENSP00000272879
- ENSG00000003400
- ENST00000286186
- ENSP00000286186
- ENST00000313728
- ENSP00000314599
- ENST00000346817
- ENSP00000237865
- ENST00000360132
- ENSP00000353250
- ENST00000374650
- ENSP00000363781
- ENST00000448480
- ENSP00000396835
- MCH4
- MCH4
- ALPS2
- FLICE2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
co-expressed gene | 0.85 | ||
PubMedID | 0.84 | ||
cell type or tissue | 0.69 | ||
tissue sample | 0.68 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.68 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 554 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 91.68 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 554 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
Pathways (127)
Reactome (14)
KEGG (5)
PathwayCommons (8)
WikiPathways (100)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | FasL/ CD95L signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Death Receptor Signalling | ||||
FasL/ CD95L signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Gene Ontology Terms (16)
Functions (5)
Components (4)
Processes (7)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (107)
1 – 10 of 107
TNFRSF10B
Novelty: 0.0006573
Score: 0.999
Data Source: Reactome,STRINGDB
TNFRSF10A
Novelty: 0.0003938
Score: 0.999
Data Source: Reactome,STRINGDB
CASP8
Family: Enzyme
Novelty: 0.00026844
Score: 0.999
Data Source: Reactome,STRINGDB
FAS
Novelty: 0.00049744
Score: 0.999
Data Source: Reactome,STRINGDB
FADD
Novelty: 0.00183502
Score: 0.992
Data Source: Reactome,STRINGDB
CFLAR
Novelty: 0.00120225
Score: 0.99
Data Source: STRINGDB
CASP3
Family: Enzyme
Novelty: 0.00004276
Score: 0.988
Data Source: STRINGDB
CASP7
Family: Enzyme
Novelty: 0.00186906
Score: 0.988
Data Source: STRINGDB
FASLG
Novelty: 0.00036473
Score: 0.981
Data Source: Reactome,STRINGDB
RIPK1
Family: Kinase
Novelty: 0.00302762
Score: 0.974
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 91.68
PubMed score by year
PubTator Score 206.31
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDL
1-70
LSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD
70-140
SLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQG
140-210
EEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNR
210-280
NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDC
280-350
FVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
350-420
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTV
420-490
WGAKQISATSLPTAISAQTPRPPMRRWSSVS
490-521
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
Find similar targets by: